Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.34 |
| ▸ | MME | P08473 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653481 | 0.93 | MERTK (0.34) | AGTR1ADORA3ADORA2BALDH1A1LMNA | |
| SCHEMBL648999 | 0.86 | ADORA3 (0.37) | AGTR1ADORA3ADORA2BADORA1PPARG | |
| SCHEMBL651281 | 0.85 | ADORA3 (0.37) | AGTR1MMEADORA3ADORA2BADORA1 | |
| SCHEMBL650385 | 0.84 | ADORA3 (0.36) | AGTR1ADORA3ADORA2BADORA1PPARG | |
| SCHEMBL650059 | 0.84 | AGTR1 (0.37) | AGTR1MMEADORA3ADORA2BADORA1 | |
| SCHEMBL652064 | 0.83 | ITGB1 (0.31) | ADORA3ADORA2B | |
| SCHEMBL650087 | 0.83 | ADORA3 (0.35) | AGTR1ADORA3ADORA2BADORA1PPARG | |
| SCHEMBL651088 | 0.79 | LTB4R2 (0.40) | AGTR1MMEPPARGLTB4R2 | |
| SCHEMBL652331 | 0.78 | DRD2 (0.35) | AGTR1ADORA2B | |
| SCHEMBL4764000 | 0.78 | ALDH1A1 (0.42) | ADORA3ADORA2BADORA1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |