Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577287 | 0.93 | LMNA (0.55) | ENPP2LMNAPTGS2PTGS1CA12 | |
| SCHEMBL904087 | 0.82 | ESR2 (0.56) | ENPP2PTGS2PTGS1HSD17B2 | |
| SCHEMBL1581335 | 0.81 | POLB (0.54) | ENPP2LMNAPTGS2PTGS1CA12 | |
| SCHEMBL1535 | 0.80 | ENPP2 (1.00) | ENPP2LMNAPTGS2PTGS1CA12 | |
| SCHEMBL6514553 | 0.79 | ENPP2 (0.64) | ENPP2LMNAPTGS2PTGS1CA12 | |
| SCHEMBL29598983 | 0.77 | GAA (0.57) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL68932 | 0.77 | GAA (0.57) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL9341624 | 0.77 | GAA (0.57) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL8177042 | 0.76 | LMNA (0.50) | ENPP2LMNAPTGS2ALDH1A1MAPT | |
| SCHEMBL1807429 | 0.75 | ALDH1A1 (0.59) | LMNAPTGS2PTGS1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005023762-A1 | PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2005-03-17 | — | — | WO | disclosed |