Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577287 | 0.85 | LMNA (0.55) | PTGS2ENPP2ACLYPTGS1HSD17B2 | |
| SCHEMBL5715742 | 0.83 | APP (0.56) | PTGS2ENPP2 | |
| SCHEMBL6513992 | 0.82 | ENPP2 (0.64) | PTGS2ENPP2PTGS1HSD17B2 | |
| SCHEMBL10068013 | 0.80 | HSD17B1 (0.53) | ESR2PTGS2ENPP2ESR1HSD17B1 | |
| SCHEMBL8055957 | 0.79 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL386673 | 0.79 | KIF11 (0.61) | ESR2PTGS2ENPP2ESR1PTGS1 | |
| SCHEMBL28184683 | 0.78 | AVPR2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL28202577 | 0.78 | ESR2 (0.77) | ESR2ESR1HSD17B1HSD17B2HDAC2 | |
| SCHEMBL278316 | 0.78 | ESR2 (0.77) | ESR2ESR1HSD17B1HSD17B2HDAC2 | |
| SCHEMBL29911026 | 0.78 | ESR2 (0.77) | ESR2ESR1HSD17B1HSD17B2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102432598-A | Tricyclic compound, preparation method thereof and pharmaceutical application thereof | JIANGSU HENGRUI MEDICINE CO | 2012-05-02 | — | — | CN | disclosed |
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |