Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20023731 | 0.87 | MAP4K4 (0.44) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL20559469 | 0.87 | MAP4K4 (0.44) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL31253295 | 0.80 | MAP4K4 (0.46) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL18237381 | 0.80 | MAP4K4 (0.33) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL18238798 | 0.77 | MAP4K4 (0.35) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL27476855 | 0.77 | ALDH1A1 (0.40) | TP53MAPTALDH1A1MEN1TSHR | |
| SCHEMBL30621189 | 0.77 | SLC6A2 (0.40) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL3351957 | 0.75 | MAP4K4 (0.41) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL3351953 | 0.75 | MAP4K4 (0.41) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL434570 | 0.75 | MAP4K4 (0.54) | MAP4K4ABL1MAPK8CSNK1A1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445504-A1 | ENANTIOMERIC COMPOSITIONS OF 2-AMINO-1-(2-ISOPROPYLPYRAZOLO[1,5-a]PYRIDIN-3-YL)PROPAN-1-ONE AND RELATED METHODS | MediciNova, Inc. (US) | 2012-05-02 | — | — | EP | claimed |
| WO-2010151551-A1 | ENANTIOMERIC COMPOSITIONS OF 2-AMINO-1-(2-ISOPROPYLPYRAZOLO[1,5-a]PYRIDIN-3-YL)PROPAN-1-ONE AND RELATED METHODS | MEDICINOVA, INC. (US) | 2010-12-29 | — | — | WO | claimed |
| US-20100324082-A1 | ENANTIOMERIC COMPOSITIONS OF 2-AMINO-1-(2-ISOPROPYLPYRAZOLO[1,5-a]PYRIDIN-3-YL)PROPAN-1-ONE AND RELATED METHODS | MEDICINOVA, INC. | 2010-12-23 | — | — | US | claimed |
| JP-62267286-A | — | — | None | — | — | JP | disclosed |
| WO-2024151833-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | CEREVEL THERAPEUTICS, LLC (US) | 2024-07-18 | — | — | WO | disclosed |
| US-20240239811-A1 | 5-(5-(PIPERIDIN-4-YL)THIENO[3,2-C]PYRAZOL-2-YL]INDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE T | REMIX THERAPEUTICS INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240226106-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES (US) | 2024-07-11 | — | — | US | disclosed |
| US-20240199604-A1 | SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-06-20 | — | — | US | disclosed |
| US-20240199604-A1 | SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-06-20 | — | — | US | disclosed |
| WO-2024059249-A1 | M4 ACTIVATORS/MODULATORS AND USES THEREOF | CEREVEL THERAPEUTICS, LLC (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2023220131-A2 | PI3Kα INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| EP-0302792-A2 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |
| JP-S62267286-A | NOVEL HYDROXYPYRAZOLOPYRIDINE DERIVATIVE | KYORIN PHARMACEUT CO LTD | 1987-11-19 | — | — | JP | disclosed |
| EP-0118916-B1 | PYRAZOLO(1,5-A)PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1987-08-12 | — | — | EP | disclosed |
| US-4680398-A | Pyrazolo[1,5-a]pyridines and benzimidazoles, useful as antiallergic agents | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1987-07-14 | — | — | US | disclosed |
| EP-0191401-A2 | Novel antiallergic agents and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1986-08-20 | — | — | EP | disclosed |
| US-4578392-A | SRS-A ANTAGONISTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| EP-0118916-A2 | Pyrazolo(1,5-a)pyridine derivatives, process for their preparation and compositions containing them | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1984-09-19 | — | — | EP | disclosed |
| US-4097483-A | HYPOTENSIVE AND ANTISPASMODIC AGENT | KYORIN PHARMACEUTICAL CO., LTD. (JA) | 1978-06-27 | — | — | US | disclosed |
| US-4028370-A | SMOOTH MUSCLE RELAXANTS, CEREBRAL AND CORONARY DILATORS, HYPOTENSIVE AGENTS | KYORIN PHARMACEUTICAL CO., LTD. (JA) | 1977-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240199604-A1 | SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS | MAPT, HTT, PSEN1 | MAP4K4 3484/4885ABL1 3168/4885MAPK8 4684/4885 |
| US-20100324082-A1 | ENANTIOMERIC COMPOSITIONS OF 2-AMINO-1-(2-ISOPROPYLPYRAZOLO[1,5-a]PYRIDIN-3-YL)PROPAN-1-ONE AND RELATED METHODS | OPRK1, OPRL1, OPRD1 | MAP4K4 1383/4885ABL1 1812/4885MAPK8 2206/4885 |
| US-20240226106-A1 | INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | MAP4K4 355/4885ABL1 1849/4885MAPK8 2553/4885 |
| US-20240239811-A1 | 5-(5-(PIPERIDIN-4-YL)THIENO[3,2-C]PYRAZOL-2-YL]INDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE T | HNRNPAB, HNRNPC, HNRNPA1 | MAP4K4 4478/4885ABL1 2007/4885MAPK8 4447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.