Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511218 | 0.86 | ZDHHC2 (0.38) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL9407113 | 0.81 | KMT2A (0.48) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL10521222 | 0.81 | KMT2A (0.48) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL7901795 | 0.80 | ALDH1A1 (0.45) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL9647538 | 0.79 | KMT2A (0.43) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL3795321 | 0.76 | MGLL (0.57) | KMT2AALDH1A1MAPTMGLLNPC1 | |
| SCHEMBL8372727 | 0.76 | MGLL (0.57) | KMT2AALDH1A1MAPTMGLLNPC1 | |
| SCHEMBL5576290 | 0.75 | ELANE (0.46) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL9646952 | 0.72 | MAPT (0.54) | KMT2AALDH1A1LMNAMAPTHSD17B10 | |
| SCHEMBL1679233 | 0.71 | ZDHHC2 (0.40) | EPHX2MGLLNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050151286-A1 | Gradient refrective-index plastic rod and method for making the same | NATIONAL CHENG KUNG UNIVERSITY (TW) | 2005-07-14 | — | — | US | disclosed |