Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC2 | Q9UIJ5 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511218 | 0.85 | ZDHHC2 (0.38) | ZDHHC2ZDHHC20TGM2EPHX2MGLL | |
| SCHEMBL9487568 | 0.76 | THRB (0.44) | TGM2NPC1RAB9A | |
| SCHEMBL7901795 | 0.75 | ALDH1A1 (0.45) | — | |
| SCHEMBL6514850 | 0.71 | KMT2A (0.36) | EPHX2MGLLNPC1RAB9A | |
| SCHEMBL9487566 | 0.70 | THRB (0.45) | TGM2RAB9A | |
| SCHEMBL11097209 | 0.68 | CNR1 (0.47) | ZDHHC2CNR1CNR2EPHX2 | |
| SCHEMBL9646952 | 0.67 | MAPT (0.54) | PTGS2 | |
| SCHEMBL9407113 | 0.66 | KMT2A (0.48) | NPC1RAB9A | |
| SCHEMBL10521222 | 0.66 | KMT2A (0.48) | NPC1RAB9A | |
| SCHEMBL28662763 | 0.66 | ZDHHC20 (0.47) | ZDHHC2ZDHHC20TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461619-B1 | IMPROVED STRUCTURED-FUNCTIONAL BONDING MATRICES FOR BIOMOLECULES | FRAUNHOFER GES FORSCHUNG (DE) | 2011-04-27 | — | — | EP | disclosed |
| EP-1299426-B1 | IMPROVED MICROGELS AND FILMS | FRAUNHOFER GES FORSCHUNG (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-7368295-B2 | Nanoparticles comprising biologically active TNF which is immobilized on the same | FRAUNHOFER-GESELLSCHAFT ZUR FODERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2008-05-06 | — | — | US | disclosed |
| US-20050048570-A1 | Structured-functional bonding matrices for biomolecules | FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN | 2005-03-03 | — | — | US | disclosed |
| US-20040265392-A1 | Nanoparticles comprising biologically active tnf which is immobilized on the same | FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2004-12-30 | — | — | US | disclosed |
| EP-1461619-A2 | IMPROVED STRUCTURED-FUNCTIONAL BONDING MATRICES FOR BIOMOLECULES | FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003056336-A2 | IMPROVED STRUCTURED-FUNCTIONAL BONDING MATRICES FOR BIOMOLECULES | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2003-07-10 | — | — | WO | disclosed |