SCHEMBL6517103

SCHEMBL6517103

Cc1cn([C@H]2C[C@H](OP(=O)(O)O)[C@@H](CO)O2)c(=O)nc1N

nearest known ligand 0.48

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ RNASE1 P07998 1/20 0.45
▸ DNMT1 P26358 4/20 0.44
▸ ADRB1 P08588 1/20 0.44
▸ TK1 P04183 1/20 0.43
▸ P2RY1 P47900 1/20 0.42
▸ DNMT3B Q9UBC3 1/20 0.42
▸ POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10331938 1.00 RNASE1 (0.45) RNASE1DNMT1ADRB1TK1P2RY1
SCHEMBL19464715 0.92 RNASE1 (0.43) RNASE1DNMT1ADRB1TK1DNMT3B
SCHEMBL30817489 0.92 RNASE1 (0.43) RNASE1DNMT1ADRB1TK1DNMT3B
SCHEMBL17052648 0.92 RNASE1 (0.43) RNASE1DNMT1ADRB1TK1DNMT3B
SCHEMBL17056236 0.92 RNASE1 (0.43) RNASE1DNMT1ADRB1TK1DNMT3B
SCHEMBL19884492 0.91 P2RY1 (0.42) TK1P2RY1
SCHEMBL24517423 0.89 RNASE1 (0.46) RNASE1DNMT1ADRB1TK1DNMT3B
SCHEMBL13646172 0.88 RNASE1 (0.46) RNASE1DNMT1ADRB1TK1DNMT3B
SCHEMBL31685415 0.88 DNMT1 (0.45) DNMT1ADRB1DNMT3BPOLB
SCHEMBL14773848 0.88 RNASE1 (0.46) RNASE1DNMT1ADRB1TK1DNMT3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025068557-A1 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF CANAVAN DISEASE CONTERA PHARMA A/S (DK) 2025-04-03 — — WO claimed
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE TEAM MEDICAL, LLC 2025-09-18 — — US disclosed
EP-4594491-A2 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF CANAVAN DISEASE Contera Pharma A/S (DK) 2025-08-06 — — EP disclosed
US-20250236871-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES ALNYLAM PHARMACEUTICALS, INC. (US) 2025-07-24 — — US disclosed
WO-2025068557-A1 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF CANAVAN DISEASE CONTERA PHARMA A/S (DK) 2025-04-03 — — WO disclosed
US-12221607-B2 Multi-targeted single entity conjugates ALNYLAM PHARMACEUTICALS, INC. (US) 2025-02-11 — — US disclosed
US-20240116973-A1 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2024-04-11 — — US disclosed
WO-2024068997-A2 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF CANAVAN DISEASE CONTERA PHARMA A/S (DK) 2024-04-04 — — WO disclosed
US-20220106593-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES ALNYLAM PHARMACEUTICALS, INC. (US) 2022-04-07 — — US disclosed
EP-3919619-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES Alnylam Pharmaceuticals, Inc. (US) 2021-12-08 — — EP disclosed
EP-3324980-B1 MULTI-TARGETED SINGLE ENTITY CONJUGATES ALNYLAM PHARMACEUTICALS INC (US) 2021-11-10 — — EP disclosed
US-11053495-B2 Multi-targeted single entity conjugates ALNYLAM PHARMACEUTICALS, INC. (US) 2021-07-06 — — US disclosed
US-20180208927-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES ALNYLAM PHARMACEUTICALS, INC. (US) 2018-07-26 — — US disclosed
US-20050003378-A1 Inhibitor of demethylase, antitumorigenic agent, and an in vitro assay for demethylase inhibitors MCGILL UNIVERSITY (CA) 2005-01-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250236871-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES SNRPE, DDX21, RNMT RNASE1 40/4885DNMT1 327/4885ADRB1 3762/4885
US-20220106593-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES SNRPE, DDX21, RNMT RNASE1 40/4885DNMT1 327/4885ADRB1 3762/4885
US-12221607-B2 Multi-targeted single entity conjugates SNRPE, DDX21, RNMT RNASE1 40/4885DNMT1 327/4885ADRB1 3762/4885
US-20240116973-A1 MODIFIED OLIGONUCLEOTIDES ADAR, EIF2AK2, TRDMT1 RNASE1 5/4885DNMT1 111/4885ADRB1 4661/4885
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE SYNCRIP, SNRPA, RNASE1 RNASE1 3/4885DNMT1 3133/4885ADRB1 4506/4885
US-11053495-B2 Multi-targeted single entity conjugates SNRPE, DDX21, RNMT RNASE1 40/4885DNMT1 327/4885ADRB1 3762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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