Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | UBE2N | P61088 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL778350 | 0.78 | MAPK1 (0.47) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL29630093 | 0.78 | MAPK1 (0.47) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL5551931 | 0.76 | MAPK1 (0.55) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL677114 | 0.74 | MAPK1 (0.42) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL80891 | 0.73 | MAPK1 (0.48) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL8189951 | 0.73 | MAPK1 (0.44) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL29481306 | 0.73 | MAPK1 (0.48) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL9353500 | 0.73 | MAPK1 (0.44) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL9353505 | 0.73 | MAPT (0.46) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL474029 | 0.73 | MAPK1 (0.48) | MAPK1SMN1; SMN2NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861384-B2 | Process for preparation of a salt-like chemical compound and its use in catalyst systems for preparing polyolefins | BASELL POLYOLEFINE GMBH (DE) | 2005-03-01 | — | — | US | disclosed |
| US-20040072975-A1 | Salt-like chemical compound, its preparation and its use in catalyst systems for preparing polyolefins | BASELL POLYPROPYLEN GMBH (DE) | 2004-04-15 | — | — | US | disclosed |
| US-20040048992-A1 | Process for preparation of salt-like chemical compound, and its use in catalyst systems for preparing polyolefins | EQUISTAR CHEMICALS, LP | 2004-03-11 | — | — | US | disclosed |
| US-20040023940-A1 | Non-metallocene compounds, method for the production thereof and use of the same for the polymerisation of olefins | EQUISTAR CHEMICALS, LP | 2004-02-05 | — | — | US | disclosed |
| US-20030144434-A1 | Chemical products suited for use as co-catalysts, method for the preparation thereof and their use in catalyst systems for producing polyolefins | EQUISTAR CHEMICALS, LP | 2003-07-31 | — | — | US | disclosed |
| US-20030069426-A1 | Saline chemical composition, method for producing the same and the use thereof in catalyst systems for producing polyolefins | SCHOTTEK JORG (DE) | 2003-04-10 | — | — | US | disclosed |
| US-20030013913-A1 | Chemical compound, method for the production thereof and its use in catalyst systems for producing polyolefins | EQUISTAR CHEMICALS, LP | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144434-A1 | Chemical products suited for use as co-catalysts, method for the preparation thereof and their use in catalyst systems for producing polyolefins | CBR1, COX6C, CBR3 | MAPK1 4081/4885SMN1; SMN2 3760/4885NPSR1 3297/4885 |
| US-20030069426-A1 | Saline chemical composition, method for producing the same and the use thereof in catalyst systems for producing polyolefins | CLIC1, HACL2, ADH1C | MAPK1 275/4885SMN1; SMN2 3120/4885NPSR1 1630/4885 |
| US-20040023940-A1 | Non-metallocene compounds, method for the production thereof and use of the same for the polymerisation of olefins | SOAT2, NOTUM, SOAT1 | MAPK1 3677/4885SMN1; SMN2 2598/4885NPSR1 3978/4885 |
| US-20030013913-A1 | Chemical compound, method for the production thereof and its use in catalyst systems for producing polyolefins | SCO2, CNOT1, CYC1 | MAPK1 352/4885SMN1; SMN2 3830/4885NPSR1 2737/4885 |
| US-20040048992-A1 | Process for preparation of salt-like chemical compound, and its use in catalyst systems for preparing polyolefins | CLIC1, HACL2, RFC1 | MAPK1 260/4885SMN1; SMN2 3640/4885NPSR1 2467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.