SCHEMBL6519873

SCHEMBL6519873

NC(=O)C[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 0.53
PTPN1 P18031 2/20 0.52
PTGS1 P23219 3/20 0.51
ALPI P09923 1/20 0.51
PKM P14618 1/20 0.51
XIAP P98170 1/20 0.51
ITGB3 P05106 1/20 0.51
ITGA2B P08514 1/20 0.51
TPH1 P17752 3/20 0.49
GRB2 P62993 1/20 0.46
ALOX15 P16050 3/20 0.45
HIF1A Q16665 3/20 0.45
KDM4E B2RXH2 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
USP2 O75604 1/20 0.45
EGFR P00533 1/20 0.45
LCK P06239 1/20 0.45
FYN P06241 1/20 0.45
ADORA3 P0DMS8 1/20 0.45
HTR2A P28223 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Asparagine SCHEMBL7758514 0.99 SLC7A5 (0.51) SLC7A5PTPN1PTGS1ALPIPKM
Glutamine SCHEMBL8134265 0.92 ALOX15 (0.47) SLC7A5PTPN1PTGS1ALPIPKM
SCHEMBL16972711 0.86 SLC7A5 (0.50) SLC7A5PTPN1PTGS1ALPIPKM
SCHEMBL1537414 0.86 SLC7A5 (0.50) SLC7A5PTPN1PTGS1ALPIPKM
Phenylalanine SCHEMBL5699042 0.85 SLC7A5 (0.69) SLC7A5PTPN1PTGS1ALPIPKM
Phenylalanine SCHEMBL5608077 0.85 SLC7A5 (0.69) SLC7A5PTPN1PTGS1ALPIPKM
SCHEMBL1679320 0.85 SLC7A5 (0.56) SLC7A5PTPN1PTGS1ALPIPKM
SCHEMBL1003560 0.85 SLC7A5 (0.69) SLC7A5PTPN1PTGS1ALPIPKM
SCHEMBL829349 0.84 SLC7A5 (0.51) SLC7A5PTPN1PTGS1ALPIPKM
SCHEMBL9120090 0.84 SLC7A5 (0.54) SLC7A5PTPN1PTGS1ALPIPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5861483-A POLYPEPTIDES WHICH INCLUDE A HEMOGLOBIN ALPHA CHAIN WHEREIN THE C-TERMINAL HYDROPHOBIC DOMAIN HAS BEEN MODIFIED PRO-NEURON, INC. (US) 1999-01-19 US claimed
EP-3183229-A1 APOE4-TARGETED THERAPUTICS THAT INCREASE SIRT1 The Regents Of The University Of California (US) 2017-06-28 EP disclosed
EP-3102611-A1 HUMANIZED BETA-AMYLOID BINDING MOLECULES AND USES THEREOF Cangene Corporation (CA) 2016-12-14 EP disclosed
WO-2016028910-A1 APOE4-TARGETED THERAPUTICS THAT INCREASE SIRT1 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-02-25 WO disclosed
WO-2015113169-A1 HUMANIZED BETA-AMYLOID BINDING MOLECULES AND USES THEREOF CNJ HOLDINGS, INC. (CA) 2015-08-06 WO disclosed
EP-2717895-A1 THERAPEUTIC COMPOUNDS FOR IMMUNOMODULATION Aurigene Discovery Technologies Limited (IN) 2014-04-16 EP disclosed
WO-2012168944-A1 THERAPEUTIC COMPOUNDS FOR IMMUNOMODULATION AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2012-12-13 WO disclosed
CN-1227259-C Propanolamine derivatives linked to bile acids for the treatment of lipid metabolism disorders AVENTIS PHARMA GMBH (DE) 2005-11-16 CN disclosed
US-20050042626-A1 Novel human kinase proteins and polynucleotides encoding the same DONOHO GREGORY (US) 2005-02-24 US disclosed
CN-1173951-C Substituted 1,3-diaryl-2-pyridine-2-yl-3-(pyridine-2-ylamino)-propanol derivatives, methods for their production, pharmaceutical compositions containing the same and their use ���ĵ�˹ҩ��¹����޹�˾ 2004-11-03 CN disclosed
EP-0983365-A1 ENZYME DERIVED FROM THERMOPHILIC ORGANISMS THAT FUNCTIONS AS A CHROMOSOMAL REPLICASE, AND PREPARATION AND USES THEREOF THE ROCKEFELLER UNIVERSITY (US) 2000-03-08 EP disclosed
WO-1999053074-A1 ENZYME DERIVED FROM THERMOPHILIC ORGANISMS THAT FUNCTIONS AS A CHROMOSOMAL REPLICASE, AND PREPARATION AND USES THEREOF THE ROCKFELLER UNIVERSITY (US) 1999-10-21 WO disclosed
WO-1999011796-A1 HNK-1 SULFOTRANSFERASE AND METHODS OF USE THEREFOR ACORDA THERAPEUTICS (US) 1999-03-11 WO disclosed
WO-1999007739-A2 DNA ENCODING THE HUMAN SYNAPSIN III GENE AND USES THEREOF THE ROCKEFELLER UNIVERSITY (US) 1999-02-18 WO disclosed
WO-1998045452-A2 ENZYME DERIVED FROM THERMOPHILIC ORGANISMS THAT FUNCTIONS AS A CHROMOSOMAL REPLICASE, AND PREPARATION AND USES THEREOF THE ROCKFELLER UNIVERSITY (US) 1998-10-15 WO disclosed
WO-1998029547-A1 MODULATORS OF RADIAL GLIA-ASTROCYTE DIFFERENTIATION AND TRANSFORMATION, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF THE ROCKEFELLER UNIVERSITY (US) 1998-07-09 WO disclosed
CN-1030703-C Neurokinin A antagonists MERRELL DOW PHARMA (US) 1996-01-17 CN disclosed
US-5192798-A Lipophilic polyamines useful for treating hypercholesterolemia THE UPJOHN COMPANY (US) 1993-03-09 US disclosed
EP-0529031-A1 IMPROVED INHIBITORS OF THROMBIN BIOGEN, INC. (US) 1993-03-03 EP disclosed
WO-1992013952-A1 IMPROVED INHIBITORS OF THROMBIN BIOGEN, INC. (US) 1992-08-20 WO disclosed