SCHEMBL652231

SCHEMBL652231

NC(=S)Nc1ccc(Br)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.63
ALDH1A1 P00352 5/20 0.60
TP53 P04637 1/20 0.60
TYR P14679 1/20 0.60
TSHR P16473 1/20 0.60
TAS2R38 P59533 1/20 0.60
HSD17B10 Q99714 1/20 0.60
CYP3A4 P08684 2/20 0.59
CYP2C19 P33261 2/20 0.59
CYP2D6 P10635 1/20 0.59
CYP2C9 P11712 1/20 0.59
HPGD P15428 1/20 0.59
ALOX12 P18054 1/20 0.59
MAPT P10636 4/20 0.57
MAOA P21397 1/20 0.57
MAOB P27338 1/20 0.57
KMT2A Q03164 4/20 0.55
MEN1 O00255 3/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
HTT P42858 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20536629 0.88 ALDH1A1 (0.81) IDO1ALDH1A1TP53TYRTSHR
SCHEMBL725810 0.87 ALDH1A1 (0.75) ALDH1A1TP53TYRTSHRTAS2R38
SCHEMBL26156233 0.81 MAPT (0.62) IDO1ALDH1A1TSHRTAS2R38CYP3A4
SCHEMBL5455602 0.80 MAPT (0.83) IDO1ALDH1A1CYP3A4CYP2C19CYP2D6
SCHEMBL8956372 0.80 MAPT (0.83) IDO1ALDH1A1CYP3A4CYP2C19CYP2D6
SCHEMBL5463340 0.80 IDO1 (0.61) IDO1ALDH1A1CYP3A4CYP2C19CYP2D6
SCHEMBL18745950 0.79 ALDH1A1 (0.58) IDO1ALDH1A1TP53TYRTSHR
SCHEMBL23752426 0.78 MAPT (0.65) IDO1ALDH1A1CYP3A4CYP2C19CYP2C9
SCHEMBL1822006 0.78 ALDH1A1 (0.65) ALDH1A1TP53TYRTSHRTAS2R38
SCHEMBL12071790 0.78 ALDH1A1 (0.62) IDO1ALDH1A1TP53TYRTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117841474-A Breathable composite fiber fabric and preparation method thereof 苏州婉玲服饰有限公司 2024-04-09 CN claimed
CN-116789889-A Polyacrylamide polymer, preparation method thereof, movable gel and application 中国石油化工股份有限公司 2023-09-22 CN claimed
CN-114432901-B Composite membrane with acid resistance and alkali resistance as well as preparation method and application thereof 中国石油化工股份有限公司 2023-04-11 CN claimed
CN-114432901-A Composite membrane with acid resistance and alkali resistance as well as preparation method and application thereof 中国石油化工股份有限公司 2022-05-06 CN claimed
CN-112250661-B Method for catalytically synthesizing lactide 南京大学 2021-11-02 CN claimed
CN-112250661-A Method for catalytically synthesizing lactide 南京大学 2021-01-22 CN claimed
US-20250092020-A1 IDO/TDO Inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-03-20 US disclosed
US-12209079-B2 IDO/TDO inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-01-28 US disclosed
CN-107629022-B Antibacterial synergist and preparation method and application thereof 上海医药工业研究院 2024-11-12 CN disclosed
CN-118619952-A Aloperine derivative, preparation method, pharmaceutical composition and application thereof 中国医学科学院药物研究所 2024-09-10 CN disclosed
CN-117841474-A Breathable composite fiber fabric and preparation method thereof 苏州婉玲服饰有限公司 2024-04-09 CN disclosed
CN-117841474-A Breathable composite fiber fabric and preparation method thereof 苏州婉玲服饰有限公司 2024-04-09 CN disclosed
CN-117164480-A Method for preparing cyanamide and mercaptan 华南理工大学 2023-12-05 CN disclosed
WO-2004110350-A2 COMPOUDS AND USES THEREOF IN MODULATING AMYLOID BETA TORREYPINES THERAPEUTICS, INC. (US) 2004-12-23 WO disclosed
US-20030153568-A1 Benzothiazole derivatives BASF AKTIENGESELLSCHAFT LUDWIGSHAFEN, GERMANY 2003-08-14 US disclosed
CN-1422262-A 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors ABBOTT GMBH & CO KG (DE) 2003-06-04 CN disclosed
EP-1254123-A1 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS Abbott GmbH & Co. KG (DE) 2002-11-06 EP disclosed
WO-2001057008-A1 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) 2001-08-09 WO disclosed
US-4563533-A FROM CORRESPONDING PHENYLTHIOUREAS HOECHST AKTIENGESELLSCHAFT (DE) 1986-01-07 US disclosed
US-4255565-A REACTION OF 5-AMINO-1-B-D-RIBOFURANOSYL-4-CYANOIMIDAZOLE AND AN N-CARBO-SUBSTITUTED CYANAMIDE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1981-03-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209079-B2 IDO/TDO inhibitor IDO1, IDO2, TDO2 IDO1 1/4885ALDH1A1 3331/4885TP53 405/4885
US-20030153568-A1 Benzothiazole derivatives TK1, FLT1, CDK1 IDO1 644/4885ALDH1A1 712/4885TP53 300/4885
US-20250092020-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 IDO1 1/4885ALDH1A1 3331/4885TP53 405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.