Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.53 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.48 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584065 | 0.85 | PLOD2 (0.70) | PLOD2PLOD3PLOD1TSHRALDH1A1 | |
| SCHEMBL3247389 | 0.81 | PLOD2 (0.60) | PLOD2PLOD3PLOD1TSHRSMN1; SMN2 | |
| SCHEMBL22804709 | 0.80 | PLOD2 (0.58) | PLOD2PLOD3PLOD1CYP3A4MAPT | |
| SCHEMBL276803 | 0.76 | SMN1; SMN2 (0.61) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1593867 | 0.75 | PLOD2 (0.70) | PLOD2PLOD3PLOD1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10596544 | 0.75 | TSHR (0.56) | TSHRSMN1; SMN2ABCB11CYP1A2CYP3A4 | |
| SCHEMBL4587003 | 0.75 | PLOD2 (0.60) | PLOD2PLOD3PLOD1ALDH1A1MAPT | |
| SCHEMBL22804864 | 0.74 | NR4A2 (0.61) | PLOD2SMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1115952 | 0.74 | GAA (0.52) | PLOD2PLOD3PLOD1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10613378 | 0.74 | PLOD2 (0.68) | PLOD2PLOD3PLOD1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005027918-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS COMPRISING COMBINATIONS OF 2-ALKYLIDENE-19-NOR-VITAMIN D DERIVATIVES AND A CYCLOOXGENASE-2 INHIBITOR | PFIZER PRODUCTS INC. (US) | 2005-03-31 | — | — | WO | disclosed |