SCHEMBL6526952

SCHEMBL6526952

COC(=O)C1=C(OC)CCc2ccccc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.51
KDM4E B2RXH2 6/20 0.51
HPGD P15428 4/20 0.51
L3MBTL1 Q9Y468 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.43
MAPT P10636 5/20 0.42
RAB9A P51151 4/20 0.42
FGFR1 P11362 2/20 0.42
SRC P12931 2/20 0.42
FGFR2 P21802 2/20 0.42
FGFR4 P22455 2/20 0.42
FGFR3 P22607 2/20 0.42
NPC1 O15118 2/20 0.41
CES1 P23141 1/20 0.40
TSHR P16473 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
LMNA P02545 1/20 0.39
NOTUM Q6P988 1/20 0.39
GAA P10253 2/20 0.38
SRD5A1 P18405 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11099181 0.82 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL6654078 0.82 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL5395844 0.74 CA1 (0.49) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL8028626 0.73 FGFR1 (0.44) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL27617877 0.72 ALDH1A1 (0.56) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL10932406 0.72 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL9257523 0.72 CYP17A1 (0.46) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL5230608 0.69 L3MBTL1 (0.49) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL1821797 0.68 FGFR1 (0.39) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2
SCHEMBL24744334 0.68 ALDH1A1 (0.51) ALDH1A1KDM4EHPGDL3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005023799-A1 FUSED BICYCLIC CARBOXAMIDE DERIVATIVES AND METHODS OF THEIR USE ADOLOR CORPORATION (US) 2005-03-17 WO disclosed