Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508189 | 0.84 | KCNH3 (0.41) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6528847 | 0.84 | SYK (0.43) | MEN1KMT2ACHRNA7 | |
| SCHEMBL6508192 | 0.84 | KCNH3 (0.41) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6528931 | 0.84 | KCNH3 (0.41) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6530404 | 0.82 | IDH2 (0.43) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6527570 | 0.82 | IDH2 (0.43) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6529551 | 0.81 | CHRNA7 (0.35) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6532662 | 0.81 | CTSK (0.42) | MAPT | |
| SCHEMBL6531461 | 0.81 | EGFR (0.39) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6528181 | 0.81 | TBK1 (0.35) | MAPTTP53POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |