Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL998384 | 0.85 | — | — | |
| Guanidine SCHEMBL9837086 | 0.82 | — | — | |
| Guanidine SCHEMBL1903839 | 0.78 | TSHR (0.31) | — | |
| Guanidine SCHEMBL56028 | 0.78 | — | — | |
| Guanidine SCHEMBL29044101 | 0.78 | TSHR (0.31) | — | |
| Guanidine SCHEMBL6708027 | 0.78 | CA1 (0.33) | — | |
| Guanidine SCHEMBL6851202 | 0.75 | — | — | |
| Guanidine SCHEMBL31206959 | 0.75 | — | — | |
| Guanidine SCHEMBL7755519 | 0.75 | — | — | |
| Guanidine SCHEMBL6529495 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101935648-B | Method and kit for extracting ribonucleic acid (RNA) | YUANPINGHAO TIANJIN BIOLOG TECHNOLOGY CO LTD | 2013-04-17 | — | — | CN | disclosed |
| US-20120045777-A1 | NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| US-8003334-B2 | Methods for identifying compounds which bind to TANGO294 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| CN-101935648-A | Method and kit for extracting ribonucleic acid (RNA) | YUANPINGHAO TIANJIN BIOLOG TECHNOLOGY CO LTD | 2011-01-05 | — | — | CN | disclosed |
| US-20100279313-A1 | Novel secreted immunomodulatory proteins and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100062487-A1 | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses | MILLENNIUM PHARMACEUTICALS, INC. | 2010-03-11 | — | — | US | disclosed |
| US-7547766-B2 | Anti-tango294 antibodies and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7408038-B2 | Secreted immunomodulatory proteins | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20070092514-A1 | Novel secreted immunomodulatory proteins and uses thereof | BUSFIELD SAMANTHA J | 2007-04-26 | — | — | US | disclosed |
| US-7202029-B2 | Nucleic acids encoding human TANGO 195 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1352240-A2 | CLONING AND EXPRESSION OF A NEW MCP RECEPTOR IN GLIAL CELLS | Rijksuniversiteit Groningen (NL) | 2003-10-15 | — | — | EP | disclosed |
| US-20030113865-A1 | Novel secreted immunomodulatory proteins and uses thereof | MILLENNIUM PHARMACEUTICALS, INC., A DELAWARE CORPORATION | 2003-06-19 | — | — | US | disclosed |
| US-20030022279-A1 | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses | MILLENNIUM PHARMACEUTICALS, INC. | 2003-01-30 | — | — | US | disclosed |
| WO-2002057779-A9 | CLONING AND EXPRESSION OF A NEW MCP RECEPTOR IN GLIAL CELLS | UNIV GRONINGEN (NL) | 2002-11-21 | — | — | WO | disclosed |
| US-20020155526-A1 | Novel secreted immunomodulatory proteins and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2002-10-24 | — | — | US | disclosed |
| US-20020132297-A1 | Novel molecules of the herpesvirus-entry-mediator-related protein family and use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2002-09-19 | — | — | US | disclosed |
| WO-2002057779-A2 | CLONING AND EXPRESSION OF A NEW MCP RECEPTOR IN GLIAL CELLS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2002-07-25 | — | — | WO | disclosed |
| EP-1109904-A1 | NOVEL MOLECULES OF THE HERPES VIRUS-ENTRY-MEDIATOR-RELATED PROTEIN FAMILY AND USES THEREOF | Millennium Biotherapeutics, Inc. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000014230-A9 | NOVEL MOLECULES OF THE HERPES VIRUS-ENTRY-MEDIATOR-RELATED PROTEIN FAMILY AND USES THEREOF | MILLENNIUM PHARM INC (US) | 2000-08-17 | — | — | WO | disclosed |
| WO-2000014230-A1 | NOVEL MOLECULES OF THE HERPES VIRUS-ENTRY-MEDIATOR-RELATED PROTEIN FAMILY AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |