Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.34 |
| ▸ | GLP1R | P43220 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1625056 | 0.86 | PGK1 (0.40) | ALDH1A1AGTR1AGTR2NPC1PGK1 | |
| SCHEMBL1623967 | 0.85 | PGK1 (0.40) | ALDH1A1AGTR1AGTR2NPC1PGK1 | |
| SCHEMBL6531348 | 0.84 | RXRA (0.42) | ALDH1A1AGTR1AGTR2NPC1PGK1 | |
| SCHEMBL1625560 | 0.82 | NPC1 (0.39) | ALDH1A1AGTR1AGTR2NPC1PGK1 | |
| SCHEMBL7100074 | 0.80 | NPC1 (0.42) | ALDH1A1NPC1PGK1MAPTLMNA | |
| SCHEMBL6051169 | 0.77 | MEN1 (0.37) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL7100556 | 0.73 | MAPT (0.39) | ALDH1A1AGTR1AGTR2NPC1PGK1 | |
| SCHEMBL27618366 | 0.72 | DCTPP1 (0.40) | ALDH1A1NPC1PGK1MAPTLMNA | |
| SCHEMBL1624773 | 0.72 | MEN1 (0.58) | AGTR1AGTR2LMNAMEN1KMT2A | |
| SCHEMBL1624249 | 0.71 | P2RX3 (0.36) | AGTR1AGTR2PPARGPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |