SCHEMBL6532725

SCHEMBL6532725

C=CC(=O)N1CCN(c2c(F)cc(-n3cc(CN4C(=O)c5ccccc5C4=O)nn3)cc2F)CC1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TYR P14679 4/20 0.39
PTGS2 P35354 5/20 0.38
ALOX15 P16050 1/20 0.38
MEN1 O00255 1/20 0.38
GAA P10253 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ACHE P22303 1/20 0.37
DRD2 P14416 1/20 0.36
DRD4 P21917 1/20 0.36
DRD3 P35462 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KRAS P01116 2/20 0.36
HTT P42858 1/20 0.36
JAK3 P52333 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6533967 0.89 ADRA1D (0.42) TYRPTGS2ALOX15HTTJAK3
SCHEMBL6532434 0.85 TYR (0.38) TYRPTGS2ALOX15MEN1GAA
SCHEMBL6534106 0.84 KDM1A (0.44)
SCHEMBL6530629 0.80 TYR (0.34) TYRPTGS2ALOX15MEN1GAA
SCHEMBL6532784 0.74 RBP4 (0.41) TYRPTGS2ALOX15HTT
SCHEMBL6529845 0.74 GPR119 (0.46) PTGS2
SCHEMBL5623713 0.71 ALDH1A1 (0.45) TYRALOX15SMN1; SMN2HSD17B10
SCHEMBL6527396 0.70 ADRA1D (0.37) PTGS2ALOX15HTT
SCHEMBL6528269 0.70 GRM1 (0.41) TYRPTGS2ALOX15DRD2DRD4
SCHEMBL6529525 0.69 GRM1 (0.55)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082892-A2 TRIAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S LABORATORIES LTD. (IN) 2005-09-09 WO disclosed