Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 3/20 | 0.34 |
| ▸ | APAF1 | O14727 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL11583629 | 0.92 | DNMT1 (0.41) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL3100107 | 0.90 | DNMT1 (0.44) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL4082601 | 0.89 | DNMT1 (0.39) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL112498 | 0.89 | DNMT1 (0.39) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL11545270 | 0.87 | DNMT1 (0.42) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL322828 | 0.87 | DNMT1 (0.42) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL16419 | 0.86 | MAPT (0.42) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL10583104 | 0.86 | DNMT1 (0.47) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL4608905 | 0.86 | DNMT1 (0.43) | DNMT1TP53MAPTHTTSTAT3 | |
| Triaziquone SCHEMBL10414999 | 0.85 | MAPT (0.41) | DNMT1TP53MAPTHTTSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113304132-A | Special dialysate for treating cardiovascular and cerebrovascular diseases of renal dialysis patients | 北京畅盛医药科技有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2020166678-A1 | COSMETIC INGREDIENT, COSMETIC, AND PRODUCTION METHOD FOR COSMETIC | ミヨシ油脂株式会社 | 2020-08-20 | — | — | WO | disclosed |
| EP-1165636-A4 | BISMUTH CARBOXYLATES AS CATALYSTS FOR CROSSLINKED BLOCKED ISOCYANATE WATERBONE COATINGS | KING INDUSTRIES INC (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-1165636-A1 | BISMUTH CARBOXYLATES AS CATALYSTS FOR CROSSLINKED BLOCKED ISOCYANATE WATERBONE COATINGS | King Industries, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000047642-A1 | BISMUTH CARBOXYLATES AS CATALYSTS FOR CROSSLINKED BLOCKED ISOCYANATE WATERBONE COATINGS | KING INDUSTRIES, INC. (US) | 2000-08-17 | — | — | WO | disclosed |