Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7857935 | 0.77 | LMNA (0.33) | LMNACA12CA1CA2CA3 | |
| SCHEMBL2825358 | 0.77 | — | — | |
| Pivalate SCHEMBL10534446 | 0.76 | POLB (0.34) | CA12CA1CA9POLB | |
| Carbamic Acid SCHEMBL699756 | 0.73 | ACHE (0.39) | LMNACA12CA1CA2CA3 | |
| Acetic Acid SCHEMBL21834859 | 0.73 | FFAR3 (0.39) | MAPTKMT2ACA12CA1CA9 | |
| Acetic Acid SCHEMBL482738 | 0.73 | FFAR3 (0.39) | MAPTKMT2ACA12CA1CA9 | |
| SCHEMBL1906466 | 0.72 | MEN1 (0.34) | MAPTMEN1KMT2ACA12CA1 | |
| SCHEMBL4891780 | 0.72 | KDM4E (0.36) | CA12CA1CA9POLB | |
| Bicarbonate SCHEMBL14917 | 0.72 | CA1 (0.38) | LMNACA12CA1CA2CA9 | |
| Bicarbonate SCHEMBL6150295 | 0.72 | CA1 (0.38) | LMNACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1486509-A2 | Radiolabeled annexin-galactose cluster conjugates | NEORX CORPORATION (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-0799050-B1 | RADIOLABELED ANNEXIN-GALACTOSE CLUSTER CONJUGATES | NEORX CORP (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-1426062-A2 | Radiolabeled annexins | NEORX CORPORATION (US) | 2004-06-09 | — | — | EP | disclosed |
| EP-0918547-B1 | RADIOLABELED ANNEXINS | NEORX CORP (US) | 2004-03-10 | — | — | EP | disclosed |
| EP-0794788-B1 | HEPATIC-DIRECTED COMPOUNDS AND REAGENTS FOR PREPARATION THEREOF | NEORX CORP (US) | 2003-05-14 | — | — | EP | disclosed |
| US-6171577-B1 | ACCESSIBLE SULFHYDRYL GROUP; AND HEXOSE MOIETY RECOGNIZED BY A MAMMALIAN LIVER RECEPTOR, WHEREIN THE HEXOSE MOIETY IS CONJUGATED TO THE ANNEXIN. | NEORX CORPORATION | 2001-01-09 | — | — | US | disclosed |
| US-5985826-A | Methods of using hepatic-directed compounds in pretargeting strategies | NEORX CORPORATION (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0799050-A4 | RADIOLABELED ANNEXIN-GALACTOSE CLUSTER CONJUGATES | NEORX CORP (US) | 1998-06-03 | — | — | EP | disclosed |
| EP-0799050-A1 | RADIOLABELED ANNEXIN-GALACTOSE CLUSTER CONJUGATES | NEORX CORPORATION (US) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996017618-A1 | RADIOLABELED ANNEXIN-GALACTOSE CLUSTER CONJUGATES | NEORX CORPORATION (US) | 1996-06-13 | — | — | WO | disclosed |