Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 11/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538469 | 0.94 | MEN1 (0.47) | MAPTADRB1ADRB3NPC1RAB9A | |
| SCHEMBL6539353 | 0.92 | ADRB1 (0.42) | MAPTADRB1ADRB3KDM4ETDP1 | |
| SCHEMBL6539522 | 0.83 | ADRB1 (0.52) | MAPTADRB1ADRB3NPC1RAB9A | |
| SCHEMBL6539352 | 0.77 | ADRB1 (0.62) | ADRB1ADRB3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6539067 | 0.76 | ADRB1 (0.49) | ADRB1ADRB3ADRB2 | |
| SCHEMBL6540414 | 0.76 | ADRB1 (0.53) | ADRB1ADRB3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6539338 | 0.75 | ADRB1 (0.39) | ADRB1ADRB3KDM4ENPC1RAB9A | |
| SCHEMBL6539288 | 0.73 | ADRB1 (0.44) | MAPTADRB1ADRB3ADRB2 | |
| SCHEMBL6539324 | 0.73 | ADRB3 (0.80) | MAPTADRB1ADRB3NPC1RAB9A | |
| SCHEMBL6539708 | 0.72 | ADRB3 (0.36) | ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6826033-B2 | BETA 3 ADRENERGIC RECEPTOR AGONISTS; TREATMENT OF POLLAKIURIA, URINARY INCONTINENCE, OBESITY OR DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20040037022-A1 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2004-02-26 | — | — | US | disclosed |