Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538684 | 0.83 | ADRB1 (0.44) | ADRB1ADRB3ADRB2NPC1RAB9A | |
| SCHEMBL6539708 | 0.81 | ADRB3 (0.36) | ADRB3 | |
| SCHEMBL6539211 | 0.80 | ADRB1 (0.54) | ADRB1ADRB3ADRB2ABCG2ALDH1A1 | |
| SCHEMBL6539214 | 0.80 | ADRB1 (0.54) | ADRB1ADRB3ADRB2ABCG2ALDH1A1 | |
| SCHEMBL6539353 | 0.77 | ADRB1 (0.42) | ADRB1ADRB3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6539595 | 0.75 | MAPT (0.48) | ADRB1ADRB3ADRB2NPC1RAB9A | |
| SCHEMBL6538469 | 0.73 | MEN1 (0.47) | ADRB1ADRB3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6539067 | 0.71 | ADRB1 (0.49) | ADRB1ADRB3ADRB2 | |
| SCHEMBL6539522 | 0.69 | ADRB1 (0.52) | ADRB1ADRB3ADRB2NPC1RAB9A | |
| SCHEMBL18651963 | 0.68 | ALOX5 (0.36) | ADRB3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6826033-B2 | BETA 3 ADRENERGIC RECEPTOR AGONISTS; TREATMENT OF POLLAKIURIA, URINARY INCONTINENCE, OBESITY OR DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20040037022-A1 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2004-02-26 | — | — | US | disclosed |