Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL96263 | 0.90 | CA12 (0.46) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL542743 | 0.84 | CA12 (0.54) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL9432845 | 0.82 | CA12 (0.46) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL11240437 | 0.81 | ALDH1A1 (0.52) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL9400732 | 0.80 | CA12 (0.48) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL3621282 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL1224664 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL8880040 | 0.79 | ALDH1A1 (0.61) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL6539776 | 0.78 | ALDH1A1 (0.54) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL1819894 | 0.78 | ALDH1A1 (0.67) | ALDH1A1HPGDCA12CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741757-B1 | DIHYDROINDOLIZINONE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2023-07-26 | — | — | EP | disclosed |
| CN-111630052-B | Dihydroindazinone derivatives | 第一三共株式会社 | 2023-04-18 | — | — | CN | disclosed |
| US-11530211-B2 | Dihydroindolizinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-12-20 | — | — | US | disclosed |
| EP-3998107-A1 | METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES | Tokyo Institute of Technology (JP) | 2022-05-18 | — | — | EP | disclosed |
| CN-114040966-A | Method for producing insulin-producing cell using dihydroindolizinone derivative | 国立大学法人东京工业大学 | 2022-02-11 | — | — | CN | disclosed |
| US-20210053965-A1 | DIHYDROINDOLIZINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-02-25 | — | — | US | disclosed |
| WO-2021006268-A1 | METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES | 国立大学法人東京工業大学 | 2021-01-14 | — | — | WO | disclosed |
| EP-3741757-A1 | DIHYDROINDOLIZINONE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2020-11-25 | — | — | EP | disclosed |
| CN-111630052-A | Dihydroindazinone derivatives | 第一三共株式会社 | 2020-09-04 | — | — | CN | disclosed |
| US-6812235-B2 | 2-ACYLAMINO- BETA -ALANINE DERIVATIVES AND A PHARMACEUTICALLY ACCEPTABLE SALT, USEFUL AS FIBRINOGEN RECEPTOR ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-02 | — | — | US | disclosed |
| US-20030018193-A1 | Beta-alanine derivatives and their use as receptor anatgonists | ASTELLAS PHARMA INC. (JP) | 2003-01-23 | — | — | US | disclosed |
| EP-1255748-A1 | BETA-ALANINE DERIVATIVES AND THEIR USE AS RECEPTOR ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060813-A1 | BETA-ALANINE DERIVATIVES AND THEIR USE AS RECEPTOR ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-08-23 | — | — | WO | disclosed |
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530211-B2 | Dihydroindolizinone derivative | INSR, GPR119, IAPP | ALDH1A1 55/4885HPGD 316/4885CA12 3048/4885 |
| US-20030018193-A1 | Beta-alanine derivatives and their use as receptor anatgonists | ARRB1, ADRB1, GLRB | ALDH1A1 578/4885HPGD 1448/4885CA12 937/4885 |
| US-20210053965-A1 | DIHYDROINDOLIZINONE DERIVATIVE | INSR, GPR119, IAPP | ALDH1A1 55/4885HPGD 316/4885CA12 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.