SCHEMBL6542176

SCHEMBL6542176

O=C(Oc1ccccc1)Oc1cc2cc(Cl)ccc2n1C(=O)Oc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OGT O15294 1/20 0.51
ALDH1A1 P00352 4/20 0.41
KMT2A Q03164 2/20 0.41
KDM4E B2RXH2 2/20 0.41
GAA P10253 1/20 0.39
CCR2 P41597 3/20 0.39
MAPT P10636 1/20 0.39
PKM P14618 1/20 0.39
TSHR P16473 1/20 0.39
MAPK1 P28482 1/20 0.39
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
BCHE P06276 2/20 0.36
PHGDH O43175 2/20 0.36
PPARG P37231 3/20 0.36
PPARD Q03181 2/20 0.36
PPARA Q07869 2/20 0.36
FNTA P49354 1/20 0.35
FNTB P49356 1/20 0.35
AKR1C3 P42330 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5805599 0.85 ALDH1A1 (0.46) OGTALDH1A1KMT2AKDM4EGAA
SCHEMBL2484841 0.79 CCR2 (0.40) OGTALDH1A1KMT2ACCR2HTT
SCHEMBL8818368 0.77 ALDH1A1 (0.48) ALDH1A1KMT2AGAACCR2MAPK1
SCHEMBL2484224 0.75 LMNA (0.52) ALDH1A1KMT2AKDM4EGAACCR2
SCHEMBL8818348 0.73 ALDH1A1 (0.39) ALDH1A1KMT2ACCR2MAPK1HPGD
SCHEMBL11959128 0.72 PTGER1 (0.41) ALDH1A1KMT2ACCR2PPARGPPARD
SCHEMBL29130669 0.72 SMN1; SMN2 (0.43) KMT2AGAAMAPTHPGDHTT
SCHEMBL815429 0.70 TAAR1 (0.51) ALDH1A1KMT2AMAPTBCHEPPARG
Chlorobenzene SCHEMBL6386765 0.68 TSHR (0.50) ALDH1A1KMT2AKDM4EMAPTTSHR
SCHEMBL4470879 0.68 OGT (1.00) OGTALDH1A1KMT2AKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023246876-A1 MEDICAL USE OF FORMAMIDE DERIVATIVES, FORMAMIDE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 上海科技大学 2023-12-28 WO disclosed
CN-117285520-A Medical use of carboxamide derivative, carboxamide derivative and pharmaceutical composition containing carboxamide derivative 上海科技大学 2023-12-26 CN disclosed
EP-1223809-A4 METHODS OF TREATING HAIR LOSS COMPRISING ADMINISTERING INDOLINE COMPOUND UNIV TEXAS SOUTHWESTERN MED CT (US) 2004-03-03 EP disclosed
EP-1223809-A1 METHODS OF TREATING HAIR LOSS COMPRISING ADMINISTERING INDOLINE COMPOUND UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) 2002-07-24 EP disclosed
WO-2001030151-A1 METHODS OF TREATING HAIR LOSS COMPRISING ADMINISTERING INDOLINE COMPOUND THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) 2001-05-03 WO disclosed
WO-1997036895-A1 PROCESS FOR THE PREPARATION OF TENIDAP EGIS Gyógyszergyár Rt. (HU) 1997-10-09 WO disclosed