Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | CFD | P00746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543386 | 0.89 | KDM4E (0.63) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL6542663 | 0.87 | KDM4E (0.69) | FLT3KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL6599162 | 0.82 | KDM4E (0.77) | XDHFLT3KDM4EALDH1A1HPGD | |
| SCHEMBL6543194 | 0.80 | ALOX15 (0.61) | FLT3KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4314106 | 0.78 | XDH (0.61) | XDHFLT3KDM4EALDH1A1HPGD | |
| SCHEMBL6542823 | 0.77 | NR1H4 (0.56) | FLT3KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL1104006 | 0.77 | PDGFRB (0.77) | XDHFLT3KDM4EALDH1A1HPGD | |
| SCHEMBL31361409 | 0.77 | PDGFRB (0.77) | XDHFLT3KDM4EALDH1A1HPGD | |
| SCHEMBL30411777 | 0.75 | NR1H4 (0.64) | NPC1RAB9AL3MBTL1NR1H4 | |
| SCHEMBL975839 | 0.75 | NR1H4 (0.64) | NPC1RAB9AL3MBTL1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187607-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| US-6469046-B1 | FABH INHIBITORS WHICH ARE USEFUL AS ANTIBIOTICS FOR THE TREATMENT OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | disclosed |
| EP-1187607-A1 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000078309-A1 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-28 | — | — | WO | disclosed |