Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 4/20 | 0.53 |
| ▸ | MMP2 | P08253 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543194 | 0.91 | ALOX15 (0.61) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL6543205 | 0.89 | XDH (0.62) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL6542663 | 0.85 | KDM4E (0.69) | KDM4EALDH1A1HPGDLMNAHSD17B10 | |
| SCHEMBL9263164 | 0.83 | KDM4E (0.80) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL710398 | 0.83 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL30452851 | 0.81 | MET (0.56) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL488122 | 0.81 | MET (0.56) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL2769403 | 0.80 | KDM4E (0.70) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL862913 | 0.80 | KDM4E (0.74) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL31287835 | 0.80 | KDM4E (0.60) | KDM4EALDH1A1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187607-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| US-6608059-B1 | Treating bacterial infections | SMITHKLINE BEECHAM CORPORATION | 2003-08-19 | — | — | US | disclosed |
| US-6469046-B1 | FABH INHIBITORS WHICH ARE USEFUL AS ANTIBIOTICS FOR THE TREATMENT OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | disclosed |
| EP-1187607-A1 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2002000646-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-01-03 | — | — | WO | disclosed |
| WO-2000078309-A1 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-28 | — | — | WO | disclosed |