Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26124 | 0.87 | — | — | |
| SCHEMBL20838334 | 0.87 | SMN1; SMN2 (0.39) | TSHRPOLBSMN1; SMN2LMNA | |
| Acrylic Acid SCHEMBL1503448 | 0.86 | LMNA (0.48) | POLBSMN1; SMN2THRBLMNA | |
| Ethylene SCHEMBL4260362 | 0.85 | SMN1; SMN2 (0.38) | TSHRPOLBSMN1; SMN2LMNA | |
| Ethyl Fumarate SCHEMBL11362442 | 0.81 | HCAR2 (0.62) | ATMLMNAHCAR2 | |
| Acrylic Acid SCHEMBL502927 | 0.80 | LMNA (0.42) | TSHRTP53POLBSMN1; SMN2THRB | |
| SCHEMBL2200499 | 0.78 | EPHX2 (0.36) | TSHRPOLBSMN1; SMN2 | |
| Methacrylic Acid SCHEMBL644383 | 0.78 | SMN1; SMN2 (0.39) | TSHRPOLBSMN1; SMN2LMNA | |
| SCHEMBL4962068 | 0.77 | — | — | |
| SCHEMBL399595 | 0.77 | CES2 (0.46) | TSHRPOLBSMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 521 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631623-A1 | SCUFF RESISTANT COMPOSITIONS COMPRISING ETHYLENE ACID COPOLYMERS AND POLYAMIDES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2006-03-08 | — | — | EP | claimed |
| US-20050020762-A1 | Scuff resistant compositions comprising ethylene acid copolymers and polyamides | PERFORMANCE MATERIALS NA, INC. | 2005-01-27 | — | — | US | claimed |
| WO-2004113445-A1 | SCUFF RESISTANT COMPOSITIONS COMPRISING ETHYLENE ACID COPOLYMERS AND POLYAMIDES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-12-29 | — | — | WO | claimed |
| EP-0034704-A1 | Toughened polyamide blends and process for preparing the same | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-09-02 | — | — | EP | claimed |
| US-20240207689-A1 | HIGH COMPRESSION GOLF BALL CORE | ACUSHNET COMPANY (US) | 2024-06-27 | — | — | US | disclosed |
| US-20240209152-A1 | ZYLON BASED MATERIALS IN GOLF BALL | ACUSHNET COMPANY (US) | 2024-06-27 | — | — | US | disclosed |
| US-20240207688-A1 | GOLF BALL COMPONENTS INCORPORATING RECLAIMED RESOURCES AND GOLF BALLS FORMED THEREFROM | ACUSHNET COMPANY (US) | 2024-06-27 | — | — | US | disclosed |
| US-20240198182-A1 | GOLF BALLS HAVING CHROMOGENIC POLYMERS IN ONE OR MORE LAYERS | JPMORGAN CHASE BANK, N.A. | 2024-06-20 | — | — | US | disclosed |
| US-20240198183-A1 | GOLF BALLS HAVING UNIQUE EFFECT PIGMENTS IN ONE OR MORE LAYERS | JPMORGAN CHASE BANK, N.A. | 2024-06-20 | — | — | US | disclosed |
| US-20240198185-A1 | GOLF BALL INCORPORATING INORGANIC ALUMINOSILICATE CERAMIC MICROSPHERES IN AT LEAST ONE LAYER | ACUSHNET COMPANY (US) | 2024-06-20 | — | — | US | disclosed |
| US-20240198184-A1 | WHITE GOLF BALL | ACUSHNET COMPANY (US) | 2024-06-20 | — | — | US | disclosed |
| US-12005318-B1 | Golf ball coatings formed from hydroxyurethane compositions | ACUSHNET COMPANY (US) | 2024-06-11 | — | — | US | disclosed |
| WO-2005020194-A1 | METHODS FOR IDENTITY VERIFICATION USING TRANSPARENT LUMINESCENT POLYMERS | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20050042428-A1 | Methods for identity verification using transparent luminescent polymers | E. I. DU PONT DE NEMOURS AND COMPANY | 2005-02-24 | — | — | US | disclosed |
| US-20050020741-A1 | Ionomers modified with rosin and articles thereof | E. I. DU PONT DE NEMOURS AND COMPANY | 2005-01-27 | — | — | US | disclosed |
| US-20050020762-A1 | Scuff resistant compositions comprising ethylene acid copolymers and polyamides | PERFORMANCE MATERIALS NA, INC. | 2005-01-27 | — | — | US | disclosed |
| US-20050020742-A1 | Ionomers modified with rosin and articles thereof | E. I. DU PONT DE NEMOURS AND COMPANY | 2005-01-27 | — | — | US | disclosed |
| WO-2004113445-A1 | SCUFF RESISTANT COMPOSITIONS COMPRISING ETHYLENE ACID COPOLYMERS AND POLYAMIDES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-12-29 | — | — | WO | disclosed |
| WO-2004103487-A1 | ARTICLES PREPARED FROM COMPOSITIONS MODIFIED WITH ORGANIC FIBER MICROPULP | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040235586-A1 | Articles prepared from compositions modified with organic fiber micropulp | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-11-25 | — | — | US | disclosed |