Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089328 | 0.94 | AURKA (0.43) | AURKAKDM4EPOLBROCK2ROCK1 | |
| SCHEMBL2911561 | 0.88 | ROCK2 (0.40) | KDM4EPOLBROCK2ROCK1KDR | |
| SCHEMBL2913924 | 0.88 | KDR (0.36) | AURKAKDM4EPOLBROCK2ROCK1 | |
| SCHEMBL654837 | 0.87 | AURKA (0.42) | AURKAKDM4EPOLBEGLN1LMNA | |
| SCHEMBL652354 | 0.85 | AURKA (0.41) | AURKAEGLN1LMNAKITNAMPT | |
| SCHEMBL650566 | 0.85 | AURKA (0.40) | AURKAROCK1EGLN1LMNAKIT | |
| SCHEMBL652230 | 0.85 | RXFP1 (0.42) | AURKAPOLBLMNAMAPK1KIT | |
| SCHEMBL653327 | 0.82 | AURKA (0.40) | AURKALMNAMAPK1RXFP1FGFR4 | |
| SCHEMBL651483 | 0.82 | EGLN1 (0.40) | AURKAEGLN1LMNAMAPK1ATM | |
| SCHEMBL653328 | 0.82 | AURKA (0.38) | AURKAKDM4ELMNAMAPK1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | claimed |
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |