Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041005 | 0.89 | HSD11B1 (0.45) | HSD11B1HPGDDPP4ALDH1A1 | |
| SCHEMBL7046189 | 0.88 | HSD11B1 (0.47) | CNR1CNR2HSD11B1KDM4EHPGD | |
| SCHEMBL7044594 | 0.82 | DPP4 (0.47) | CNR1CNR2DPP4 | |
| SCHEMBL7041734 | 0.82 | KDM4E (0.67) | CNR1KDM4EHPGDSMN1; SMN2TGFBR1 | |
| SCHEMBL6775223 | 0.78 | CRHR1 (0.42) | CNR1HSD11B1DPP4ALDH1A1 | |
| SCHEMBL13722556 | 0.76 | CDC7 (0.46) | CNR1CNR2DPP4MAPK14 | |
| SCHEMBL7044590 | 0.76 | CNR1 (0.49) | CNR1CNR2 | |
| SCHEMBL28588376 | 0.76 | NPY5R (0.51) | CNR1CNR2HSD11B1DPP4GCGR | |
| SCHEMBL6552039 | 0.74 | CNR1 (0.47) | CNR1CNR2HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL31346722 | 0.73 | NPY5R (0.55) | CNR1CNR2HSD11B1HPGDDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482794-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | Merck & Co., Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075660-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | MERCK & CO., INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | disclosed |