Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041005 | 0.89 | HSD11B1 (0.45) | HSD11B1HPGDALDH1A1DPP4HSP90AA1 | |
| SCHEMBL6552000 | 0.88 | CNR1 (0.47) | HSD11B1KDM4EHPGDSMN1; SMN2TGFBR1 | |
| SCHEMBL7041734 | 0.82 | KDM4E (0.67) | KDM4EHPGDSMN1; SMN2TGFBR1TGFBR2 | |
| SCHEMBL7040999 | 0.81 | CRHR1 (0.44) | CNR1CNR2MAPK13GCGRMAPK12 | |
| SCHEMBL31346722 | 0.76 | NPY5R (0.55) | HSD11B1HPGDCNR1CNR2DPP4 | |
| SCHEMBL5204729 | 0.73 | NPY5R (0.54) | KDM4EHPGDSMN1; SMN2CNR1MAPK13 | |
| SCHEMBL28588376 | 0.73 | NPY5R (0.51) | HSD11B1CNR1CNR2MAPK13GCGR | |
| SCHEMBL7041748 | 0.73 | CNR1 (0.47) | CNR1CNR2 | |
| SCHEMBL6775223 | 0.72 | CRHR1 (0.42) | HSD11B1CNR1ALDH1A1DPP4HSP90AA1 | |
| SCHEMBL3949786 | 0.72 | GUSB (0.43) | HSD11B1HPGDMAPK13GCGRMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | disclosed |