SCHEMBL6552201

SCHEMBL6552201

Nc1cccc(C=C(C(=O)O)C(=O)O)c1N

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MMP2 P08253 1/20 0.37
CD44 P16070 1/20 0.34
MAPT P10636 2/20 0.33
G6PD P11413 1/20 0.33
CASP7 P55210 1/20 0.33
CASP6 P55212 1/20 0.33
GAA P10253 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HIF1A Q16665 1/20 0.33
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL433478 0.84 TP53 (0.47) TP53KDM4EMAPTGAACYP1A2
SCHEMBL16287426 0.77 TP53 (0.56) TP53KDM4ECYP1A2CYP3A4CYP2C9
SCHEMBL16796026 0.77 TP53 (0.41) TP53KDM4EMAPTGAACYP1A2
Bicarbonate SCHEMBL6665346 0.76 LMNA (0.42) MMP2CD44MAPTG6PDCASP7
SCHEMBL23453112 0.74 CD44 (0.43) CD44CASP7CYP3A4
SCHEMBL8669956 0.71 ERN1 (0.55) TP53KDM4EMMP2MAPTGAA
SCHEMBL1655785 0.70 TDP1 (0.50) CD44CASP7GAACYP3A4HTT
SCHEMBL7607193 0.69 NFKB1 (0.53) TP53KDM4EMAPT
SCHEMBL11312075 0.69 CD44 (0.46) CD44MAPTCASP7CYP3A4HIF1A
SCHEMBL9364526 0.69 KDM4E (0.43) TP53KDM4ECYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP claimed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP claimed
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP disclosed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP disclosed
EP-0841341-B1 Sunscreen agents, and cosmetic compositions containing them OREAL (FR) 1999-04-07 EP disclosed
EP-0841341-A1 Sunscreen agents, and cosmetic compositions containing them L'OREAL (FR) 1998-05-13 EP disclosed