Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11435701 | 0.85 | MAPT (0.48) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL11435704 | 0.85 | MAPT (0.48) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL6657749 | 0.83 | ALDH1A1 (0.46) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL6665605 | 0.83 | ALDH1A1 (0.46) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL11048446 | 0.83 | ALDH1A1 (0.56) | ALDH1A1KDM4EGAAL3MBTL1EPHX1 | |
| SCHEMBL6657756 | 0.83 | ALDH1A1 (0.46) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL11762907 | 0.82 | MAPT (0.45) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL3877253 | 0.80 | ALDH1A1 (0.43) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL9823973 | 0.80 | MAPT (0.46) | CES1CES2ALDH1A1KDM4EGAA | |
| SCHEMBL10613362 | 0.79 | PTPN1 (0.47) | CES1CES2ALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011559-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10011559-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2018-01-18 | — | — | US | disclosed |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2018-01-18 | — | — | US | disclosed |
| EP-2816024-B1 | Chiral amines | SUNOVION PHARMACEUTICALS INC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2016-01-21 | — | — | US | disclosed |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2016-01-21 | — | — | US | disclosed |
| EP-2747564-A1 | HERBICIDAL COMPOSITIONS COMPRISING CHLOROACETAMIDES | BASF SE (DE) | 2014-07-02 | — | — | EP | disclosed |
| US-20140057990-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-20140057990-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-8524950-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2013-09-03 | — | — | US | disclosed |
| WO-2013026811-A1 | HERBICIDAL COMPOSITIONS COMPRISING CHLOROACETAMIDES | BASF SE (DE) | 2013-02-28 | — | — | WO | disclosed |
| US-20120095106-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120095106-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-8097760-B2 | Preparation of chiral amides and amines | Sunovion Pharmacuticals Inc. (US) | 2012-01-17 | — | — | US | disclosed |
| US-8097760-B2 | Preparation of chiral amides and amines | Sunovion Pharmacuticals Inc. (US) | 2012-01-17 | — | — | US | disclosed |
| US-20090149549-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2009-06-11 | — | — | US | disclosed |
| US-20090149549-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2009-06-11 | — | — | US | disclosed |
| EP-1482800-A2 | HERBICIDE COMBINATION WITH ACYLATED AMINOPHENYLSULFONYLUREAS | Bayer CropScience GmbH (DE) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003073853-A2 | HERBICIDE COMBINATION WITH ACYLATED AMINOPHENYLSULFONYLUREAS | BAYER CROPSCIENCE GMBH (DE) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011559-B2 | Preparation of chiral amides and amines | PNMT, ALKBH5, ALKBH2 | CES1 1643/4885CES2 275/4885ALDH1A1 501/4885 |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH2, ALKBH5 | CES1 1627/4885CES2 281/4885ALDH1A1 523/4885 |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CES1 1643/4885CES2 275/4885ALDH1A1 501/4885 |
| US-20090149549-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CES1 1643/4885CES2 275/4885ALDH1A1 501/4885 |
| US-20120095106-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CES1 1643/4885CES2 275/4885ALDH1A1 501/4885 |
| US-20140057990-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | CES1 1643/4885CES2 275/4885ALDH1A1 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.