SCHEMBL6554201

SCHEMBL6554201

Nc1ccc2c(c1)C[C@H](CC(=O)O)CO2

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 5/20 0.57
ITGA2B P08514 5/20 0.57
ALOX5 P09917 1/20 0.45
MTNR1A P48039 3/20 0.43
MALT1 Q9UDY8 1/20 0.37
LTB4R Q15722 1/20 0.37
LTB4R2 Q9NPC1 1/20 0.37
HDAC1 Q13547 1/20 0.37
HTT P42858 1/20 0.35
HTR1A P08908 1/20 0.35
HTR1D P28221 1/20 0.35
HTR2C P28335 1/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
TRPV1 Q8NER1 1/20 0.34
NPC1 O15118 1/20 0.34
LMNA P02545 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PPARG P37231 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6554194 1.00 ITGB3 (0.57) ITGB3ITGA2BALOX5MTNR1AMALT1
SCHEMBL6553933 0.84 MTNR1A (0.51) ITGB3ITGA2BALOX5MTNR1AMALT1
SCHEMBL6554279 0.84 MTNR1A (0.51) ITGB3ITGA2BALOX5MTNR1AMALT1
SCHEMBL6554163 0.84 MTNR1A (0.51) ITGB3ITGA2BALOX5MTNR1AMALT1
Hydrochloric Acid SCHEMBL6555750 0.83 MTNR1A (0.50) ITGB3ITGA2BALOX5MTNR1AMALT1
SCHEMBL6554181 0.82 MTNR1A (0.44) ITGB3ITGA2BALOX5MTNR1AMALT1
SCHEMBL6553963 0.82 MTNR1A (0.44) ITGB3ITGA2BALOX5MTNR1AMALT1
SCHEMBL6555465 0.82 MTNR1A (0.44) ITGB3ITGA2BALOX5MTNR1AMALT1
Hydrochloric Acid SCHEMBL6555480 0.81 MTNR1A (0.43) ITGB3ITGA2BALOX5MTNR1AMALT1
SCHEMBL6554292 0.79 SIGMAR1 (0.51) ITGB3ITGA2BMALT1LTB4RLTB4R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0892044-B1 Esterase and its use for the production of optically active chroman compounds MITSUI CHEMICALS INC (JP) 2004-12-29 EP disclosed
US-6303349-B1 CONTACTING CHROMAN-3-ACETIC ACID ESTER WITH ESTER HYDROLASE TO HYDROLYZE TO CHROMAN-3-ACETIC ACID MITSUI CHEMICALS, INC. (JP) 2001-10-16 US disclosed
US-6060290-A DERIVED FROM BACTERIA OF GENUS PSEUDONOCARDIA MITSUI CHEMICALS INCORPORATED (JP) 2000-05-09 US disclosed
EP-0892044-A2 Esterase and its use for the production of optically active chroman compounds Mitsui Chemicals, Inc. (JP) 1999-01-20 EP disclosed