Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27525681 | 1.00 | SIGMAR1 (0.51) | SIGMAR1MALT1ITGB3ITGA2BHTR1A | |
| SCHEMBL9692869 | 0.82 | MALT1 (0.57) | SIGMAR1MALT1HDAC1ALDH1A1TP53 | |
| SCHEMBL9824678 | 0.81 | HTT (0.46) | SIGMAR1MALT1HTR1AFEN1HTT | |
| Hydrochloric Acid SCHEMBL9458541 | 0.80 | HTT (0.45) | SIGMAR1MALT1HTR1AFEN1HTT | |
| SCHEMBL2247241 | 0.80 | SIGMAR1 (0.52) | SIGMAR1MALT1HTR1AFEN1HDAC1 | |
| SCHEMBL6554194 | 0.79 | ITGB3 (0.57) | MALT1ITGB3ITGA2BHTR1AFEN1 | |
| SCHEMBL6554201 | 0.79 | ITGB3 (0.57) | MALT1ITGB3ITGA2BHTR1AFEN1 | |
| SCHEMBL29633587 | 0.79 | DGAT1 (0.47) | ALDH1A1TP53 | |
| SCHEMBL1340255 | 0.79 | DGAT1 (0.47) | ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL8578572 | 0.77 | SIGMAR1 (0.45) | SIGMAR1MALT1HTR1AFEN1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303349-B1 | CONTACTING CHROMAN-3-ACETIC ACID ESTER WITH ESTER HYDROLASE TO HYDROLYZE TO CHROMAN-3-ACETIC ACID | MITSUI CHEMICALS, INC. (JP) | 2001-10-16 | — | — | US | claimed |
| CN-1218110-A | Novel esterase and methods for production of optically active chroman compounds | MITSUI CHEMICALS INC (JP) | 1999-06-02 | — | — | CN | claimed |
| EP-0892044-A2 | Esterase and its use for the production of optically active chroman compounds | Mitsui Chemicals, Inc. (JP) | 1999-01-20 | — | — | EP | claimed |
| JP-11206398-A | — | — | None | — | — | JP | disclosed |
| CN-101486683-B | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | Sanitary Material R&D Management Co.,Ltd. (JP) | 2011-12-21 | — | — | CN | disclosed |
| CN-101486683-A | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | CN | disclosed |
| CN-100473647-C | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI CO LTD (JP) | 2009-04-01 | — | — | CN | disclosed |
| EP-0892044-B1 | Esterase and its use for the production of optically active chroman compounds | MITSUI CHEMICALS INC (JP) | 2004-12-29 | — | — | EP | disclosed |
| CN-1458924-A | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI CO LTD (JP) | 2003-11-26 | — | — | CN | disclosed |
| US-6303349-B1 | CONTACTING CHROMAN-3-ACETIC ACID ESTER WITH ESTER HYDROLASE TO HYDROLYZE TO CHROMAN-3-ACETIC ACID | MITSUI CHEMICALS, INC. (JP) | 2001-10-16 | — | — | US | disclosed |
| US-6303349-B1 | CONTACTING CHROMAN-3-ACETIC ACID ESTER WITH ESTER HYDROLASE TO HYDROLYZE TO CHROMAN-3-ACETIC ACID | MITSUI CHEMICALS, INC. (JP) | 2001-10-16 | — | — | US | disclosed |
| EP-0892044-A2 | Esterase and its use for the production of optically active chroman compounds | Mitsui Chemicals, Inc. (JP) | 1999-01-20 | — | — | EP | disclosed |
| EP-0892044-A2 | Esterase and its use for the production of optically active chroman compounds | Mitsui Chemicals, Inc. (JP) | 1999-01-20 | — | — | EP | disclosed |
| US-5843947-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-12-01 | — | — | US | disclosed |
| US-5719145-A | FIBRINOGEN ANTAGONIST FOR TREATMENT OF THROMBOSIS, RESTENOSIS AFTER ANGIOPLASTY OR CORONARY RECANALIZATION; WATER SOLUBILITY, ORAL ADMINISTRATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5712294-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| US-5112855-A | Nootropic Agents | CIBA-GEIGY CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0252005-B1 | HYDROGENATED 1-BENZOOXACYCLOALKYL-PYRIDINE CARBOXYLIC-ACID COMPOUNDS | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| US-4957928-A | NOOTROPIC AGENTS, COGNITION ACTIVATORS | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| EP-0252005-A1 | Hydrogenated 1-benzooxacycloalkyl-pyridine carboxylic-acid compounds | CIBA-GEIGY AG (CH) | 1988-01-07 | — | — | EP | disclosed |