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Histidine

Histidine

SCHEMBL6554647

CC(C)C[C@H](N)C(=O)O.C[C@H](N)C(=O)OC[C@H](N)C(=O)OC(=O)[C@@H](N)CS.NCC(=O)O.NCC(=O)O.NCC(=O)OC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL7757149 0.96 — —
Histidine SCHEMBL8428513 0.88 — —
Histidine SCHEMBL7753919 0.87 — —
Histidine SCHEMBL7759763 0.87 GSR (0.32) —
Histidine SCHEMBL6554652 0.87 — —
Histidine SCHEMBL7757156 0.87 — —
Histidine SCHEMBL8428516 0.84 GHSR (0.30) —
Histidine SCHEMBL20817128 0.83 — —
Histidine SCHEMBL28798985 0.82 GSR (0.32) —
Histidine SCHEMBL6554680 0.81 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0955311-A2 Peptide vaccine for canine allergy IDEXX LABORATORIES, INC. (US) 1999-11-10 — — EP claimed
EP-0957111-B1 Specific binding proteins for treating canine allergy IDEXX LAB INC (US) 2004-12-29 — — EP disclosed
US-6734287-B1 SPECIFICALLY BIND TO AN ISOLATED AND PURIFIED PEPTIDE COMPRISING A LEUCINE POSITIONED TWO PEPTIDE BONDS AWAY FROM A TYROSINE-ARGININE PAIR; PROVIDE IMMUNITY TO DOG'S IMMUNOGLOBULIN E MOLECULES IDEXX LABORATORIES, INC. 2004-05-11 — — US disclosed
EP-1082340-A1 PEPTIDE VACCINE FOR CANINE ALLERGY IDEXX LABORATORIES, INC. (US) 2001-03-14 — — EP disclosed
WO-2000058349-A1 PEPTIDE VACCINE FOR CANINE ALLERGY IDEXX LABORATORIES, INC. (US) 2000-10-05 — — WO disclosed
EP-0957111-A2 Specific binding proteins for treating canine allergy IDEXX LABORATORIES, INC. (US) 1999-11-17 — — EP disclosed
EP-0955311-A2 Peptide vaccine for canine allergy IDEXX LABORATORIES, INC. (US) 1999-11-10 — — EP disclosed