Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL8084688 | 0.85 | — | — | |
| Tyrosine SCHEMBL6554731 | 0.84 | SLC7A5 (0.36) | — | |
| Asparagine SCHEMBL3252545 | 0.83 | REN (0.30) | — | |
| Histidine SCHEMBL6544594 | 0.83 | — | — | |
| Tyrosine SCHEMBL6554685 | 0.82 | ITGA4 (0.33) | — | |
| Proline SCHEMBL7630910 | 0.82 | ITGB3 (0.31) | — | |
| Histidine SCHEMBL6554647 | 0.81 | — | — | |
| Histidine SCHEMBL6544571 | 0.81 | — | — | |
| Tyrosine SCHEMBL6554735 | 0.80 | SLC7A5 (0.39) | — | |
| Tyrosine SCHEMBL6157195 | 0.80 | TYR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957111-B1 | Specific binding proteins for treating canine allergy | IDEXX LAB INC (US) | 2004-12-29 | — | — | EP | claimed |
| EP-1082340-A1 | PEPTIDE VACCINE FOR CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-2000058349-A1 | PEPTIDE VACCINE FOR CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2000-10-05 | — | — | WO | claimed |
| EP-0955311-A2 | Peptide vaccine for canine allergy | IDEXX LABORATORIES, INC. (US) | 1999-11-10 | — | — | EP | claimed |
| EP-0957111-B1 | Specific binding proteins for treating canine allergy | IDEXX LAB INC (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6734287-B1 | SPECIFICALLY BIND TO AN ISOLATED AND PURIFIED PEPTIDE COMPRISING A LEUCINE POSITIONED TWO PEPTIDE BONDS AWAY FROM A TYROSINE-ARGININE PAIR; PROVIDE IMMUNITY TO DOG'S IMMUNOGLOBULIN E MOLECULES | IDEXX LABORATORIES, INC. | 2004-05-11 | — | — | US | disclosed |
| WO-2000058365-A9 | SPECIFIC BINDING PROTEINS FOR TREATING CANINE ALLERGY | IDEXX LAB INC (US) | 2001-11-15 | — | — | WO | disclosed |
| EP-1082346-A1 | SPECIFIC BINDING PROTEINS FOR TREATING CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-1082340-A1 | PEPTIDE VACCINE FOR CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-2000058365-A1 | SPECIFIC BINDING PROTEINS FOR TREATING CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000058349-A1 | PEPTIDE VACCINE FOR CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2000-10-05 | — | — | WO | disclosed |
| EP-0957111-A2 | Specific binding proteins for treating canine allergy | IDEXX LABORATORIES, INC. (US) | 1999-11-17 | — | — | EP | disclosed |
| EP-0955311-A2 | Peptide vaccine for canine allergy | IDEXX LABORATORIES, INC. (US) | 1999-11-10 | — | — | EP | disclosed |