Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GALK1 | P51570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6553946 | 0.86 | KDM4E (0.38) | ALDH1A1CYP2A6KDM4EHPGDMAPT | |
| Hydrochloric Acid SCHEMBL6554982 | 0.86 | KDM4E (0.38) | ALDH1A1CYP2A6KDM4EHPGDMAPT | |
| Hydrochloric Acid SCHEMBL6889960 | 0.86 | HTR7 (0.33) | HTR7HTR1ACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL5951783 | 0.84 | HTR7 (0.35) | HTR7HTR1ACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL6886266 | 0.82 | HTR7 (0.34) | HTR7HTR1ACA12CA1CA2 | |
| Fluoride Ion SCHEMBL7640470 | 0.81 | HTR7 (0.35) | HTR7HTR1ACA12CA1CA2 | |
| SCHEMBL17952999 | 0.80 | ALDH1A1 (0.37) | HTR7HTR1ACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL4094244 | 0.77 | ALDH1A1 (0.35) | HTR7HTR1ACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL4068167 | 0.77 | ALDH1A1 (0.35) | HTR7HTR1ACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL4060835 | 0.77 | ALDH1A1 (0.35) | HTR7HTR1ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773237-B1 | Olefin polymerization catalyst system | MITSUI CHEMICALS INC (JP) | 2004-02-18 | — | — | EP | disclosed |