Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384490 | 0.84 | OPRM1 (0.39) | GRIA1GRIA2GRIA3GRIA4PIK3CD | |
| SCHEMBL7715035 | 0.79 | ABCB1 (0.49) | HTR1AALDH1A1THRBHPGDL3MBTL1 | |
| SCHEMBL6560074 | 0.78 | L3MBTL1 (0.31) | PIK3CDHTR1ADRD3HTR7ALDH1A1 | |
| SCHEMBL21047565 | 0.78 | HTR1A (0.48) | HTR1AALDH1A1THRBHPGDL3MBTL1 | |
| SCHEMBL21047883 | 0.78 | HTR1A (0.48) | HTR1AALDH1A1THRBHPGDL3MBTL1 | |
| SCHEMBL1732235 | 0.78 | HTR1A (0.48) | HTR1AALDH1A1THRBHPGDL3MBTL1 | |
| SCHEMBL21047618 | 0.78 | HTR1A (0.48) | HTR1AALDH1A1THRBHPGDL3MBTL1 | |
| SCHEMBL21047906 | 0.78 | HTR1A (0.48) | HTR1AALDH1A1THRBHPGDL3MBTL1 | |
| SCHEMBL8445221 | 0.77 | ALDH1A1 (0.50) | HTR1ADRD3ALDH1A1THRBHPGD | |
| SCHEMBL13600646 | 0.76 | PIK3CD (0.49) | PIK3CDSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436255-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024924-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2003-03-27 | — | — | WO | disclosed |