Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560820 | 0.86 | KCNA5 (0.36) | TRPV1KCNA5PKMCYP2D6CFTR | |
| SCHEMBL6559916 | 0.83 | TRPV1 (0.42) | TRPV1KCNA5SIRT2CYP3A4 | |
| SCHEMBL6559262 | 0.75 | TRPV1 (0.43) | TRPV1KCNA5SIRT2 | |
| SCHEMBL6558627 | 0.74 | TRPV1 (0.33) | TRPV1KCNA5SIRT2 | |
| SCHEMBL6559596 | 0.73 | KCNE1 (0.36) | — | |
| SCHEMBL6558741 | 0.73 | TRPV1 (0.33) | TRPV1KCNA5SIRT2 | |
| SCHEMBL7464900 | 0.73 | KCNE1 (0.52) | TRPV1SIRT2 | |
| SCHEMBL15867099 | 0.72 | MEN1 (0.34) | — | |
| SCHEMBL6558621 | 0.71 | TRPV1 (0.37) | TRPV1KCNA5SIRT2 | |
| SCHEMBL6603299 | 0.71 | KCNE1 (0.54) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |