Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559931 | 0.89 | KCNA5 (0.44) | TRPV1KCNA5SIRT2SMN1; SMN2KDM4E | |
| SCHEMBL6561146 | 0.88 | KCNA5 (0.41) | TRPV1KCNA5SIRT2SMN1; SMN2RAB9A | |
| SCHEMBL6558679 | 0.88 | HPGD (0.41) | TRPV1KCNA5SIRT2SMN1; SMN2KDM4E | |
| SCHEMBL6558681 | 0.84 | KCNA5 (0.42) | TRPV1KCNA5SIRT2SMN1; SMN2KDM4E | |
| SCHEMBL6559916 | 0.80 | TRPV1 (0.42) | TRPV1KCNA5SIRT2SIRT1 | |
| SCHEMBL6559277 | 0.80 | KCNE1 (0.40) | SMN1; SMN2KDM4EHSD17B10RAB9ANPC1 | |
| SCHEMBL6561155 | 0.79 | RAB9A (0.43) | SIRT2SMN1; SMN2KDM4EHSD17B10RAB9A | |
| SCHEMBL6558734 | 0.79 | TRPV1 (0.39) | TRPV1KCNA5SIRT2SMN1; SMN2KDM4E | |
| SCHEMBL6559265 | 0.78 | TRPV1 (0.38) | TRPV1KCNA5SIRT2SMN1; SMN2RAB9A | |
| SCHEMBL6559316 | 0.78 | TRPV1 (0.38) | TRPV1KCNA5SIRT2SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |