Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557683 | 0.92 | LMNA (0.51) | LMNASMN1; SMN2HPGDHTTIDO1 | |
| SCHEMBL6560301 | 0.85 | LMNA (0.52) | LMNASMN1; SMN2HTTIDO1KAT2B | |
| SCHEMBL6558125 | 0.83 | POLB (0.55) | SMN1; SMN2IDO1 | |
| SCHEMBL6559025 | 0.82 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2HTTIDO1TBXA2R | |
| SCHEMBL2851561 | 0.80 | LMNA (0.61) | LMNASMN1; SMN2HTTIDO1TGM2 | |
| SCHEMBL6558252 | 0.79 | LMNA (0.50) | LMNASMN1; SMN2HTTIDO1KAT2B | |
| SCHEMBL10550119 | 0.78 | TRPM8 (0.66) | IDO1 | |
| SCHEMBL872000 | 0.77 | NPC1 (0.55) | SMN1; SMN2MRGPRX4 | |
| Benzyl Phenethylcarbamate SCHEMBL4287199 | 0.77 | LMNA (0.73) | LMNASMN1; SMN2HTTIDO1TGM2 | |
| SCHEMBL11468285 | 0.76 | EPHX2 (0.52) | HPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391454-A1 | Substituted benzamide compounds with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1195372-A1 | N-heterocyclic substituted benzamide derivatives with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6156766-A | Benzamide compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| US-5958944-A | TREATMENT OF CIRCULATORY DISEASES IN CORONARY, CEREBRAL, RENAL AND PERIPHERAL ARTERIES, AS A THERAPEUTIC AGENT FOR HYPERTENSION, ANGINA PECTORIS, AND RENAL AND PERIPHERAL CIRCULATION DISORDER, ANTIASTHMATIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0757038-A1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |