Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | PNMT | P11086 | 8/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561214 | 0.81 | CA1 (0.56) | CA1CA2CA12CA7CA9 | |
| SCHEMBL6558753 | 0.80 | CA12 (0.61) | CA1CA2CA12CA7CA9 | |
| SCHEMBL6561215 | 0.80 | GRM7 (0.60) | CA1CA2CA12CA7CA9 | |
| SCHEMBL3803914 | 0.79 | CA1 (0.59) | CA1CA2CA12CA7CA9 | |
| SCHEMBL8008337 | 0.79 | CA1 (0.59) | CA1CA2CA12CA7CA9 | |
| SCHEMBL8370641 | 0.77 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL27744228 | 0.75 | ADRA2A (0.50) | CA1CA2CA12CA7CA9 | |
| SCHEMBL8884861 | 0.74 | GAA (0.43) | GAACA1CA2CA12CA7 | |
| SCHEMBL4736399 | 0.73 | GRIN2B (0.48) | GAAPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL4736395 | 0.73 | GRIN2B (0.48) | GAAPNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |