Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561761 | 0.83 | KEAP1 (0.53) | KEAP1LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6562122 | 0.79 | ALOX15 (0.54) | KEAP1LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6561650 | 0.79 | KEAP1 (0.53) | KEAP1LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8625192 | 0.78 | F10 (0.67) | KEAP1LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8627655 | 0.78 | KEAP1 (0.67) | KEAP1LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6562129 | 0.77 | LMNA (0.55) | KEAP1LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8626468 | 0.77 | SMN1; SMN2 (0.69) | KEAP1LMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8626109 | 0.77 | CCR9 (0.66) | KEAP1SMN1; SMN2HPGDTUBB4ATUBB | |
| SCHEMBL8626209 | 0.76 | LMNA (0.72) | KEAP1LMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8622964 | 0.76 | LMNA (0.57) | KEAP1LMNAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990645-B1 | NOVEL SULFONAMIDE DERIVATIVES | NIPPON KAYAKU KK (JP) | 2004-07-28 | — | — | EP | disclosed |
| US-6180796-B1 | TUBULIN POLYMERIZATION INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0990645-A1 | NOVEL SULFONAMIDE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-05 | — | — | EP | disclosed |