Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562125 | 0.89 | LMNA (0.60) | KEAP1LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL6561793 | 0.89 | RAB9A (0.51) | LMNASMN1; SMN2ALDH1A1HTTTP53 | |
| SCHEMBL6563618 | 0.87 | ALDH1A1 (0.53) | LMNASMN1; SMN2ALDH1A1HTTHPGD | |
| SCHEMBL6562093 | 0.87 | SMN1; SMN2 (0.54) | KEAP1LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6561743 | 0.87 | LMNA (0.53) | KEAP1LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6563639 | 0.84 | MEN1 (0.47) | LMNASMN1; SMN2ALDH1A1HTTHPGD | |
| SCHEMBL8627655 | 0.82 | KEAP1 (0.67) | KEAP1LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL8623537 | 0.81 | KEAP1 (0.56) | KEAP1LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL8626192 | 0.81 | KEAP1 (0.56) | KEAP1LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6562122 | 0.81 | ALOX15 (0.54) | KEAP1LMNASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990645-B1 | NOVEL SULFONAMIDE DERIVATIVES | NIPPON KAYAKU KK (JP) | 2004-07-28 | — | — | EP | disclosed |
| US-6180796-B1 | TUBULIN POLYMERIZATION INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0990645-A1 | NOVEL SULFONAMIDE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-05 | — | — | EP | disclosed |