Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 4/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.42 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670899 | 0.90 | PRSS1 (0.43) | PRSS1ALDH1A1F2PRSS2PRSS3 | |
| SCHEMBL6565256 | 0.89 | AKR1C3 (0.44) | PRSS1ALDH1A1MRGPRX1F2PRSS2 | |
| SCHEMBL7674188 | 0.89 | EGLN1 (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7677130 | 0.88 | PRSS1 (0.41) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7675043 | 0.87 | F7 (0.42) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6563277 | 0.87 | F2 (0.41) | PRSS1MRGPRX1F2MAPK13MAPK12 | |
| SCHEMBL7676492 | 0.87 | CCNA2 (0.41) | PRSS1ALDH1A1MRGPRX1RAB9AF2 | |
| SCHEMBL7675063 | 0.87 | F2 (0.48) | PRSS1ALDH1A1F2PRSS2PRSS3 | |
| SCHEMBL7677481 | 0.86 | F2 (0.47) | PRSS1ALDH1A1F2PRSS2PRSS3 | |
| SCHEMBL6563946 | 0.85 | KLK1 (0.42) | PRSS1ALDH1A1HPGDMRGPRX1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |