Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.45 |
| ▸ | F2 | P00734 | 6/20 | 0.45 |
| ▸ | F7 | P08709 | 4/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.44 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563625 | 0.85 | PRSS1 (0.43) | MRGPRX1PRSS1F2F7F10 | |
| SCHEMBL6563677 | 0.83 | MRGPRX1 (0.43) | MRGPRX1PRSS1F2F7F10 | |
| SCHEMBL6563461 | 0.82 | PRSS1 (0.49) | MRGPRX1PRSS1F2F7F10 | |
| SCHEMBL6565256 | 0.82 | AKR1C3 (0.44) | MRGPRX1PRSS1F2F7F10 | |
| SCHEMBL6563916 | 0.81 | TMPRSS6 (0.47) | MRGPRX1PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6563734 | 0.80 | LTB4R2 (0.45) | MRGPRX1F2 | |
| SCHEMBL6561886 | 0.80 | PLAU (0.53) | MRGPRX1F2 | |
| SCHEMBL7675063 | 0.80 | F2 (0.48) | PRSS1F2F10PRSS2PRSS3 | |
| SCHEMBL7677481 | 0.79 | F2 (0.47) | PRSS1F2F7F10PRSS2 | |
| SCHEMBL6563946 | 0.78 | KLK1 (0.42) | MRGPRX1PRSS1F2F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |