SCHEMBL6562149

SCHEMBL6562149

Nc1cc(NC(=O)Nc2cccc(S(=O)(=O)CCCl)c2)ccc1S(=O)(=O)O

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.47
CA1 P00915 11/20 0.45
CA2 P00918 11/20 0.45
CA9 Q16790 11/20 0.45
CA12 O43570 10/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CASR P41180 1/20 0.43
EPHX2 P34913 2/20 0.43
GRIK1 P39086 1/20 0.42
GRIK2 Q13002 1/20 0.42
POLB P06746 1/20 0.42
CA7 P43166 1/20 0.42
PKM P14618 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8750931 0.81 ENPP2 (0.44) CA1CA2CA9CA12MEN1
SCHEMBL10802231 0.79 CA2 (0.54) MAPTCA1CA2CA9CA12
SCHEMBL6560413 0.77 PRMT1 (0.68) MAPTCA1CA2CA9CA12
SCHEMBL6561275 0.77 TIMP3 (0.56) MAPTCA1CA2CA9CA12
SCHEMBL10802551 0.74 CASP3 (0.48) CA1CA2CA9CA12MEN1
SCHEMBL9320034 0.74 CA1 (0.51) MAPTCA1CA2CA9CA12
SCHEMBL10797634 0.73 PRMT1 (0.51) SMN1; SMN2
SCHEMBL6559697 0.73 APEX1 (0.51) MAPTCA1CA2CA9CA12
SCHEMBL9174682 0.72 CASP3 (0.40) CA1CA2CA9CA12MEN1
SCHEMBL11050144 0.72 KDM4E (0.39) MAPTMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1055710-B1 Water-soluble fibre-reactive dyestuffs, process for their preparation and their use DYSTAR TEXTILFARBEN GMBH & CO (DE) 2004-08-11 EP disclosed
US-6444794-B1 COMPLEXING WITH SUBSTRATE DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2002-09-03 US disclosed
EP-1055710-A1 Water-soluble fibre-reactive dyestuffs, process for their preparation and their use DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2000-11-29 EP disclosed
EP-0838504-B1 Water-soluble fiber-reactive dyes, process for their preparation and the use thereof DYSTAR TEXTILFARBEN GMBH & CO (DE) 2000-06-07 EP disclosed
US-6060591-A FOR DYEING A MATERIAL CONTAINING HYDROXY OR CARBOXAMIDE GROUPS OR BOTH DY STAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND K.G. (DE) 2000-05-09 US disclosed
EP-0848042-A2 Water-soluble fiber-reactive dyes, process for their preparation and the use thereof DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 1998-06-17 EP disclosed
EP-0838504-A1 Water-soluble fiber-reactive dyes, process for their preparation and the use thereof DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 1998-04-29 EP disclosed
EP-0629667-B1 Water-soluble fiber-reactive dyes, process for their preparation and the use thereof HOECHST AG (DE) 1998-02-25 EP disclosed
EP-0548795-B1 Water-soluble reactive dyes, their manufacture and their use HOECHST AG (DE) 1997-07-09 EP disclosed
EP-0374758-B1 Water soluble dyes, methods for their preparation and their use HOECHST AG (DE) 1995-05-31 EP disclosed
EP-0377166-B1 Water-soluble, fibre-reactive dyes, methods for their preparation and their use HOECHST AG (DE) 1994-03-02 EP disclosed
US-5280110-A Fiber-reactive dye HOECHST AKTIENGESELLSCHAFT (DE) 1994-01-18 US disclosed
EP-0575744-A1 Silane-containing dyestuffs, process for their preparation and their use HOECHST AKTIENGESELLSCHAFT (DE) 1993-12-29 EP disclosed
US-5243034-A Disazo dyestuffs having a triazine moiety and a fiberreactive group of vinylsulfone series HOECHST AKTIENGESELLSCHAFT (DE) 1993-09-07 US disclosed
US-5225544-A FIBER REACTIVE DYES WHICH CONTAIN A CYANOAMINOTRIAZINYL GROUP AND ONE OR TWO GROUPS OF THE VINYL SULFONE SERIES HOECHST AKTIENGESELLSCHAFT (DE) 1993-07-06 US disclosed
EP-0548792-A2 Water-soluble reactive dyes, their manufacture and their use HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-30 EP disclosed
EP-0548795-A2 Water-soluble reactive dyes, their manufacture and their use HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-30 EP disclosed
EP-0542214-A2 Water-soluble fibre-reactive dyes, process for their preparation and the use thereof HOECHST AKTIENGESELLSCHAFT (DE) 1993-05-19 EP disclosed
US-5138041-A Water-soluble fiber-reactive monoazo and disazo dyestuffs having a s-triazinylamino group and three fiber-reactive groups of the vinylsulfone series HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-11 US disclosed
EP-0377166-A1 Water-soluble, fibre-reactive dyes, methods for their preparation and their use HOECHST AKTIENGESELLSCHAFT (DE) 1990-07-11 EP disclosed