Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | GALR3 | O60755 | 2/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562124 | 0.80 | KLK5 (0.47) | KLK5KLK1ALDH1A1TSHRTP53 | |
| SCHEMBL4320699 | 0.76 | KLK1 (0.71) | KLK5KLK1RAB9AMAPTKDM4E | |
| SCHEMBL30583224 | 0.76 | KLK1 (0.71) | KLK5KLK1RAB9AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7408509 | 0.76 | KLK1 (0.70) | KLK5KLK1RAB9AMAPTKDM4E | |
| SCHEMBL6563255 | 0.75 | PRSS1 (0.44) | KLK5KLK1F10 | |
| SCHEMBL21067963 | 0.73 | HDAC1 (0.44) | KLK5KLK1TNFHDAC1HDAC6 | |
| SCHEMBL7673744 | 0.72 | ASIC3 (0.40) | KLK5KLK1F10 | |
| SCHEMBL12589583 | 0.70 | F2 (0.55) | KLK5KLK1TNFHDAC1HDAC6 | |
| SCHEMBL6561827 | 0.70 | MRGPRX1 (0.51) | F10 | |
| SCHEMBL15567678 | 0.69 | TNF (0.70) | TNFHDAC1HDAC6GALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |