Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.47 |
| ▸ | KLK1 | P06870 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BMI1 | P35226 | 1/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562437 | 0.80 | KLK5 (0.47) | KLK5KLK1TSHRHTTTP53 | |
| SCHEMBL6563913 | 0.75 | CA12 (0.33) | KLK5KLK1F2PRSS1 | |
| SCHEMBL6563277 | 0.72 | F2 (0.41) | KLK5KLK1F2ASIC3PLG | |
| SCHEMBL7071377 | 0.71 | KLK5 (0.41) | KLK5KLK1TSHRF2HPGD | |
| Hydrochloric Acid SCHEMBL6943397 | 0.71 | KLK5 (0.41) | KLK5KLK1TSHRF2HPGD | |
| SCHEMBL6563255 | 0.71 | PRSS1 (0.44) | KLK5KLK1F2ASIC3PLG | |
| SCHEMBL6563544 | 0.70 | RXRA (0.38) | F2HPGDPRSS1ALDH1A1CYP2C19 | |
| SCHEMBL6563461 | 0.70 | PRSS1 (0.49) | KLK5KLK1F2PLGPRSS1 | |
| SCHEMBL7675036 | 0.68 | F10 (0.42) | KLK5KLK1F2PLGPRSS1 | |
| SCHEMBL6561958 | 0.68 | ACACB (0.49) | KLK5KLK1F2HPGDPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |