Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561813 | 0.89 | PTPN11 (0.42) | PTPN11ACACBPTGESATR | |
| SCHEMBL6563070 | 0.84 | PTPN11 (0.44) | PTPN11NR1H4CYP17A1 | |
| SCHEMBL6563355 | 0.84 | PTPN11 (0.47) | PTPN11PTGESCYP17A1 | |
| SCHEMBL6563526 | 0.83 | PTPN11 (0.38) | PTPN11ACACBPTGES | |
| SCHEMBL6565352 | 0.82 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL7686729 | 0.82 | PTPN11 (0.43) | PTPN11ACACBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7674981 | 0.82 | ABL1 (0.43) | PTPN11ACACBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6561879 | 0.81 | PTPN11 (0.38) | PTPN11ACACBPTGESPTGDR2SMN1; SMN2 | |
| SCHEMBL6565434 | 0.81 | PTPN11 (0.41) | PTPN11PTGESMAPT | |
| SCHEMBL6565384 | 0.81 | GRM5 (0.46) | PTPN11ACACBEGLN1EPHX2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |