Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563283 | 0.89 | PTPN11 (0.46) | PTPN11ACACBPTGESATR | |
| SCHEMBL6563495 | 0.84 | PTPN11 (0.36) | PTPN11ACACBPTGESCCNCCDK8 | |
| SCHEMBL6563749 | 0.81 | ITGB3 (0.41) | ACACBATR | |
| SCHEMBL6563355 | 0.80 | PTPN11 (0.47) | PTPN11PTGES | |
| SCHEMBL6563070 | 0.80 | PTPN11 (0.44) | PTPN11NAMPT | |
| SCHEMBL6563526 | 0.79 | PTPN11 (0.38) | PTPN11ACACBPTGES | |
| SCHEMBL6561879 | 0.79 | PTPN11 (0.38) | PTPN11ACACBPTGES | |
| SCHEMBL7674981 | 0.78 | ABL1 (0.43) | PTPN11ACACBNAMPT | |
| SCHEMBL7686729 | 0.78 | PTPN11 (0.43) | PTPN11ACACBNAMPT | |
| SCHEMBL6561858 | 0.77 | GRM5 (0.47) | PTPN11NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |