Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.49 |
| ▸ | F2 | P00734 | 6/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.47 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | PLAT | P00750 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 2/20 | 0.40 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670899 | 0.93 | PRSS1 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7669552 | 0.90 | HPN (0.45) | PRSS1PLAUHPN | |
| SCHEMBL6563255 | 0.83 | PRSS1 (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6563743 | 0.82 | PRSS1 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6561827 | 0.82 | MRGPRX1 (0.51) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6561878 | 0.82 | PRSS1 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6563625 | 0.82 | PRSS1 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7674188 | 0.81 | EGLN1 (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11135905 | 0.81 | SMN1; SMN2 (0.52) | — | |
| SCHEMBL7677130 | 0.80 | PRSS1 (0.41) | PRSS1F2PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |